Prognostic role of H3K27M mutation, histone H3K27 methylation status, and EZH2 expression in diffuse spinal cord gliomas

Ishi, Yukitomo; Takamiya, Soichiro; Seki, Toshitaka; Yamazaki, Kazuyoshi; Hida, Kazutoshi; Hatanaka, Kanako C.; Ishida, Yusuke; Oda, Yoshitaka; Tanaka, Shinya; Yamaguchi, Shigeru

Prognostic role of H3K27M mutation, histone H3K27 methylation status, and EZH2 expression in diffuse spinal cord gliomas

Ishi, Yukitomo; Takamiya, Soichiro; Seki, Toshitaka et al.

Brain Tumor Pathology, 2021, 37(3), 81-88

Permalink : https://hdl.handle.net/2115/82148

このアイテムのアクセス数:804件（2026-08-07 20:59 集計）

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/82148
タイトル	Prognostic role of H3K27M mutation, histone H3K27 methylation status, and EZH2 expression in diffuse spinal cord gliomas
著者	Ishi, Yukitomo ; Takamiya, Soichiro ; Seki, Toshitaka ; Yamazaki, Kazuyoshi ; Hida, Kazutoshi ; Hatanaka, Kanako C. ; Ishida, Yusuke ; Oda, Yoshitaka ; Tanaka, Shinya ; Yamaguchi, Shigeru
e-Rad_Researcher 30812284 著者名 Ishi, Yukitomo
著者名 Takamiya, Soichiro
著者名 Seki, Toshitaka
著者名 Yamazaki, Kazuyoshi
e-Rad_Researcher 10238305 著者名 Hida, Kazutoshi
著者名 Hatanaka, Kanako C.
e-Rad_Researcher 80649088 著者名 Ishida, Yusuke
著者名 Oda, Yoshitaka
e-Rad_Researcher 70261287 著者名 Tanaka, Shinya
著者名 Yamaguchi, Shigeru
言語	英語
キーワード	Spinal cord
	Glioma
	EZH2
発行日	2021-07
出版者	Springer
収録物名	Brain Tumor Pathology
巻(号)	37(3)
ページ	81-88
抄録	The objective of this study is to clarify clinical significance of theH3F3A K27Mmutation (H3K27M) and analyze the correlation between H3K27M, H3K27me3 status, and EZH2 expression and prognosis in spinal cord gliomas. Patients with spinal cord diffuse glioma regardless of World Health Organization (WHO) grade underwent genetic analysis forH3F3A, HIST1H3B,TERTpromoter,IDH1/2, andBRAF. H3K27me3 status and EZH2 expression were analyzed through immunohistochemistry. Thereafter, the association between H3K27M, H3K27me3 status, and EZH2 expression and prognosis was retrospectively analyzed using the log-rank test. A total of 26 cases, 5 with WHO grade 4, 9 with grade 3, and 12 with grade 2 glioma, were analyzed. Although WHO grade 2 cases tended to present favorable overall survival, the difference was not statistically significant. H3K27M, which was detected in four grade 4 cases (80%) and three grade 3 cases (33%), was not associated with prognosis among grade 3 and 4 cases. Among WHO grade 2-4 cases, the combination of retained H3K27me3 and negative EZH2 expression was correlated with favorable overall survival (p = 0.03). The combination of H3K27me3 status and EZH2 expression was considered as a potential prognostic marker in WHO grade 2-4 diffuse spinal cord gliomas.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in Brain Tumor Pathology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10014-020-00369-9
PISSN	1433-7398
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s10014-020-00369-9