Simultaneous T-2* mapping of N-14- and N-15-labeled dicarboxy-PROXYLs using CW-EPR-based single-point imaging

Yokoyama, Takahito; Taguchi, Akihiro; Kubota, Harue; Stewart, Neil J.; Matsumoto, Shingo; Kirilyuk, Igor A.; Hirata, Hiroshi

Simultaneous T-2* mapping of N-14- and N-15-labeled dicarboxy-PROXYLs using CW-EPR-based single-point imaging

Yokoyama, Takahito; Taguchi, Akihiro; Kubota, Harue et al.

Journal of magnetic resonance, 2019, 305, 122-130

Permalink : https://hdl.handle.net/2115/82322

このアイテムのアクセス数:383件（2026-08-13 03:19 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
JMR-19-77Rev-1	pdf	1.05 MB	380

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/82322
タイトル	Simultaneous T-2* mapping of N-14- and N-15-labeled dicarboxy-PROXYLs using CW-EPR-based single-point imaging
著者	Yokoyama, Takahito ; Taguchi, Akihiro ; Kubota, Harue ; Stewart, Neil J. ; Matsumoto, Shingo ; Kirilyuk, Igor A. ; Hirata, Hiroshi
著者名 Yokoyama, Takahito
著者名 Taguchi, Akihiro
著者名 Kubota, Harue
著者名 Stewart, Neil J.
e-Rad_Researcher 90741041 著者名 Matsumoto, Shingo
著者名 Kirilyuk, Igor A.
e-Rad_Researcher 60250958 著者名 Hirata, Hiroshi
言語	英語
キーワード	EPR
	T-2* mapping
	Nitroxyl radical
	Single-point imaging
	Gradient-descent optimization
	Oxygenation
発行日	2019-08
出版者	Elsevier
収録物名	Journal of magnetic resonance
巻(号)	305
ページ	122-130
抄録	This article reports a method of simultaneous T-2* mapping of N-14- and N-15-labeled dicarboxy-PROXYLs using 750-MHz continuous-wave electron paramagnetic resonance (CW-EPR) imaging. To separate the spectra of N-14- and N-15-labeled dicarboxy-PROXYLs under magnetic field gradients, an optimization problem for spectral projections was formulated with the spatial total variation as a regularization term and solved using a local search based on the gradient descent algorithm. Using the single-point imaging (SPI) method with spectral projections of each radical, simultaneous T-2* mapping was performed for solution samples. Simultaneous T-2* mapping enabled visualization of the response of T-2* values to the level of dissolved oxygen in the solution. Simultaneous T-2* mapping applied to a mouse tumor model demonstrated the feasibility of the reported method for potential application to in vivo oxygenation imaging. (C) 2019 Elsevier Inc. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	©2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1090-7807
NCID	AA11113784
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.jmr.2019.06.012