Resistant maltodextrin or fructooligosaccharides promotes GLP-1 production in male rats fed a high-fat and high-sucrose diet, and partially reduces energy intake and adiposity

Hira, Tohru; Suto, Ryoya; Kishimoto, Yuka; Kanahori, Sumiko; Hara, Hiroshi

Resistant maltodextrin or fructooligosaccharides promotes GLP-1 production in male rats fed a high-fat and high-sucrose diet, and partially reduces energy intake and adiposity

Hira, Tohru; Suto, Ryoya; Kishimoto, Yuka et al.

European Journal of Nutrition, 2017, 57(3), 965-979

Permalink : https://hdl.handle.net/2115/85305

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アクセス権	open access
URI	https://hdl.handle.net/2115/85305
タイトル	Resistant maltodextrin or fructooligosaccharides promotes GLP-1 production in male rats fed a high-fat and high-sucrose diet, and partially reduces energy intake and adiposity
著者	Hira, Tohru ; Suto, Ryoya ; Kishimoto, Yuka ; Kanahori, Sumiko ; Hara, Hiroshi
e-Rad_Researcher 10396301 著者名 Hira, Tohru
著者名 Suto, Ryoya
著者名 Kishimoto, Yuka
著者名 Kanahori, Sumiko
e-Rad_Researcher 70198894 著者名 Hara, Hiroshi
言語	英語
キーワード	Resistant maltodextrin
	Fructooligosaccharides
	Glucagon-like peptide-1
	High-fat and high-sucrose diet
	Appetite
	Adiposity
発行日	2017
収録物名	European Journal of Nutrition
巻(号)	57(3)
ページ	965-979
抄録	Purpose Increasing secretion and production of glucagon-like peptide-1 (GLP-1) by continuous ingestion of certain food components has been expected to prevent glucose intolerance and obesity. In this study, we examined whether a physiological dose (5% weight in diet) of digestion-resistant maltodextrin (RMD) has a GLP-1-promoting effect in rats fed a high-fat and high-sucrose (HFS) diet. Methods Rats were fed a control diet or the HFS (30% fat, 40% sucrose wt/wt) diet supplemented with 5% RMD or fructooligosaccharides (FOS) for 8 weeks or for 8 days in separated experiments. Glucose tolerance, energy intake, plasma and tissue GLP-1 concentrations, and cecal short-chain fatty acids concentrations were assessed. Results After 4 weeks of feeding, HFS-fed rats had significantly higher glycemic response to oral glucose than control rats, but rats fed HFS?+?RMD/FOS did not (approx. 50% reduction vs HFS rats). HFS?+?RMD/FOS-fed rats had higher GLP-1 responses (~twofold) to oral glucose, than control rats. After 8 weeks, visceral adipose tissue weight was significantly higher in HFS-fed rats than control rats, while HFS?+?RMD/FOS rats had a trend of reduced gain (~50%) of the tissue weight. GLP-1 contents and luminal propionate concentrations in the large intestine increased (>twofold) by adding RMD/FOS to HFS. Eight days feeding of RMD/FOS-supplemented diets reduced energy intake (~10%) and enhanced cecal GLP-1 production (~twofold), compared to HFS diet. Conclusions The physiological dose of a prebiotic fiber promptly (within 8 days) promotes GLP-1 production in rats fed an obesogenic diet, which would help to prevent excess energy intake and fat accumulation.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at link.springer.com
PISSN	1436-6207
EISSN	1436-6215
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00394-017-1381-7