Associations between maternal mono-(2-ethylhexyl) phthalate levels, nuclear receptor gene polymorphisms, and fatty acid levels in pregnant Japanese women in the Hokkaido study

Kobayashi, Sumitaka; Sata, Fumihiro; Miyashita, Chihiro; Ikeda-Araki, Atsuko; Goudarzi, Houman; Nakajima, Tamie; Kishi, Reiko

Associations between maternal mono-(2-ethylhexyl) phthalate levels, nuclear receptor gene polymorphisms, and fatty acid levels in pregnant Japanese women in the Hokkaido study

Kobayashi, Sumitaka; Sata, Fumihiro; Miyashita, Chihiro et al.

Reproductive toxicology, 2022, 107, 22-32

Permalink : https://hdl.handle.net/2115/87639

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/87639
タイトル	Associations between maternal mono-(2-ethylhexyl) phthalate levels, nuclear receptor gene polymorphisms, and fatty acid levels in pregnant Japanese women in the Hokkaido study
著者	Kobayashi, Sumitaka ; Sata, Fumihiro ; Miyashita, Chihiro ; Ikeda-Araki, Atsuko ; Goudarzi, Houman ; Nakajima, Tamie ; Kishi, Reiko
e-Rad_Researcher 10733371 著者名 Kobayashi, Sumitaka
著者名 Sata, Fumihiro
著者名 Miyashita, Chihiro
著者名 Ikeda-Araki, Atsuko
著者名 Goudarzi, Houman
著者名 Nakajima, Tamie
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Mono-(2-ethylhexyl) phthalate
	Pregnancy
	Genotype
	Peroxisome proliferator-activated receptor coactivator 1A
	Liver X receptor beta
	Fatty acid
発行日	2022-01
出版者	Elsevier
収録物名	Reproductive toxicology
巻(号)	107
ページ	22-32
抄録	We assessed how the interaction between mono-(2-ethylhexyl) phthalate (MEHP) in maternal sera and the maternal genotypes associated with nuclear receptors affect fatty acid levels in a prospective birth cohort study of pregnant Japanese individuals (n = 437) recruited in Sapporo between 2002 and 2005. We analyzed MEHP and fatty acids using gas chromatography-mass spectrometry. Thirteen single nucleotide polymorphisms of peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma (PPARG), PPARG coactivator 1A (PPARGC1A), PPAR delta, constitutive androstane receptor, liver X receptor (LXR) alpha, and LXR beta (LXRB) were analyzed using real-time PCR. Multiple linear regression models were used to confirm the influence of log(10)-transformed MEHP levels and maternal genotypes on log(10)-transformed fatty acid levels. When the effects of the interaction between MEHP levels and the maternal PPARGC1A (rs8192678) genotype on oleic acid levels were evaluated, the estimated changes (95 % confidence intervals) in oleic acid levels against MEHP levels, maternal PPARGC1A (rs8192678)-GA/AA genotype, and the interaction between them showed a mean reduction of 0.200 (0.079, 0.322), mean reduction of 0.141 (0.000, 0.283), and mean increase of 0.145 (0.010, 0.281), respectively, after adjusting for the perfluorooctanesulfonate level. The effects of the interaction between MEHP levels and maternal LXRB (rs2303044) genotype on linoleic acid levels was also significant (p(int) = 0.010). In conclusion, the interaction between MEHP and the maternal genotypes PPARGC1A (rs8192678) and LXRB (rs2303044) decreased fatty acid levels. Further, the interaction between MEHP and PPARGC1A (rs8192678) may have a greater effect on fatty acid levels than the interaction between PFOS and PPARGC1A.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0890-6238
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.reprotox.2021.11.003