Assessment of LeadCare (R) II analysis for testing of a wide range of blood lead levels in comparison with ICP-MS analysis

Nakata, Hokuto; Nakayama, Shouta M. M.; Yabe, John; Muzandu, Kaampwe; Toyomaki, Haruya; Yohannes, Yared Beyene; Kataba, Andrew; Zyambo, Golden; Ikenaka, Yoshinori; Choongo, Kennedy; Ishizuka, Mayumi

Assessment of LeadCare (R) II analysis for testing of a wide range of blood lead levels in comparison with ICP-MS analysis

Nakata, Hokuto; Nakayama, Shouta M. M.; Yabe, John et al.

Chemosphere, 2021, 271, 129832

Permalink : https://hdl.handle.net/2115/89538

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/89538
タイトル	Assessment of LeadCare (R) II analysis for testing of a wide range of blood lead levels in comparison with ICP-MS analysis
著者	Nakata, Hokuto ; Nakayama, Shouta M. M. ; Yabe, John ; Muzandu, Kaampwe ; Toyomaki, Haruya ; Yohannes, Yared Beyene ; Kataba, Andrew ; Zyambo, Golden ; Ikenaka, Yoshinori ; Choongo, Kennedy ; Ishizuka, Mayumi
e-Rad_Researcher 60815273 著者名 Nakata, Hokuto
e-Rad_Researcher 90647629 著者名 Nakayama, Shouta M. M.
著者名 Yabe, John
著者名 Muzandu, Kaampwe
著者名 Toyomaki, Haruya
著者名 Yohannes, Yared Beyene
著者名 Kataba, Andrew
著者名 Zyambo, Golden
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
著者名 Choongo, Kennedy
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	LeadCare
	ICP-MS
	Bias
	Bland-altman analysis
	Passing-bablok regression
	Deming regression
発行日	2021-05
出版者	Elsevier
収録物名	Chemosphere
巻(号)	271
ページ	129832
抄録	The LeadCare (R) testing system, which utilizes anodic stripping voltammetry (ASV) methodology, has been widely used worldwide for cost-effective blood lead level (BLL) screening. However, some concerns have recently been issued regarding inaccurate results obtained using LeadCare (R). Hence, we aimed to evaluate the accuracy of BLL measured by LeadCare (R) II (BLLLC) by comparison with ICP-MS (BLLIM) by the Passing-Bablok regression, Deming regression, and Bland-Altman analyses by using 994 venous blood samples. BLLLC ranged from 3.3 to 162.3 mu g/dL, while BLLIM ranged from 0.8 to 154.8 mu g/dL. Although BLLLC and BLLIM exhibited a strong and positive correlation, BLLLC values were generally greater than BLLIM values, indicative of the overestimation of the LeadCare (R) analysis. A large positive bias of 19.15 +/- 8.26 mg/dL and 29.25 +/- 14.04 mu g/dL for BLLLC compared with BLLIM were recorded in the BLLLC range of 45.0-64.9 mu g/dL and for >= 65.0 mu g/dL, respectively. In contrast, a bias of <= 0.3 mu g/dL was observed at a BLLLC of less than 10.0 mu g/dL. Blood copper, cadmium, and iron levels did not exhibit an effect on the bias of BLLLC, indicative of the minimal potential interferences of the metals; these interferences are a cause for concern with the ASV method. In conclusion, LeadCare (R) analysis is thought to be a good tool for screening purposes at a lower BLL around the reference level of 5 mg/dL in the initial stage; however, conversion or retesting using a laboratory analyzer is recommended at a higher BLL for appropriate clinical evaluation and research. (C) 2021 Elsevier Ltd. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© <2021>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0045-6535
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.chemosphere.2021.129832