Serological characterization of lineage II insect-specific flaviviruses compared with pathogenic mosquito-borne flaviviruses

Tabata, Koshiro; Itakura, Yukari; Toba, Shinsuke; Uemura, Kentaro; Kishimoto, Mai; Sasaki, Michihito; Harrison, Jessica J.; Sato, Akihiko; Hall, William W.; Hall, Roy A.; Sawa, Hirofumi; Orba, Yasuko

Serological characterization of lineage II insect-specific flaviviruses compared with pathogenic mosquito-borne flaviviruses

Tabata, Koshiro; Itakura, Yukari; Toba, Shinsuke et al.

Biochemical and biophysical research communications, 2022, 616, 115-121

Permalink : https://hdl.handle.net/2115/90263

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/90263
タイトル	Serological characterization of lineage II insect-specific flaviviruses compared with pathogenic mosquito-borne flaviviruses
著者	Tabata, Koshiro ; Itakura, Yukari ; Toba, Shinsuke ; Uemura, Kentaro ; Kishimoto, Mai ; Sasaki, Michihito ; Harrison, Jessica J. ; Sato, Akihiko ; Hall, William W. ; Hall, Roy A. ; Sawa, Hirofumi ; Orba, Yasuko
著者名 Tabata, Koshiro
著者名 Itakura, Yukari
著者名 Toba, Shinsuke
著者名 Uemura, Kentaro
著者名 Kishimoto, Mai
e-Rad_Researcher 70609403 著者名 Sasaki, Michihito
著者名 Harrison, Jessica J.
著者名 Sato, Akihiko
著者名 Hall, William W.
著者名 Hall, Roy A.
e-Rad_Researcher 30292006 著者名 Sawa, Hirofumi
e-Rad_Researcher 60507169 著者名 Orba, Yasuko
言語	英語
キーワード	Lineage II insect-Specific flavivirus
	BJV
	PSFV
	Antibody
	Cross-reactivity
	Antibody-dependent enhancement (ADE)
発行日	2022-08-06
出版者	Elsevier
収録物名	Biochemical and biophysical research communications
巻(号)	616
ページ	115-121
抄録	The genus Flavivirus includes pathogenic tick- and mosquito-borne flaviviruses as well as non-pathogenic insect-specific flaviviruses (ISFVs). Phylogenetic analysis based on whole amino acid sequences has indicated that lineage II ISFVs have similarities to pathogenic flaviviruses. In this study, we used reactive analysis with immune serum against Psorophora flavivirus (PSFV) as a lineage IIa ISFV, and Barkeji virus (BJV) as a lineage IIb ISFV, to evaluate the antigenic similarity among lineage IIa and IIb ISFVs, and pathogenic mosquito-borne flaviviruses (MBFVs). Binding and antibody-dependent enhancement assays showed that anti-PSFV sera had broad cross-reactivity with MBFV antigens, while anti-BJV sera had low cross-reactivity. Both of the lineage II ISFV antisera were rarely observed to neutralize MBFVs. These results suggest that lineage IIa ISFV PSFV has more antigenic similarity to MBFVs than lineage IIb ISFV BJV.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0006-291X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbrc.2022.05.080