Five New Analogs of Streptogramin Antibiotic Viridogrisein Isolated from Streptomyces niveoruber

Yoshimura, Aya; Honda, Takumi; Wakimoto, Toshiyuki

Chemical and pharmaceutical bulletin, 2024, 72(1), 80-85

Permalink : https://hdl.handle.net/2115/92020

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アクセス権
open access
URI
https://hdl.handle.net/2115/92020
タイトル
Five New Analogs of Streptogramin Antibiotic Viridogrisein Isolated from Streptomyces niveoruber
著者
Yoshimura, Aya ; Honda, Takumi ; Wakimoto, Toshiyuki
e-Rad_Researcher
60866416
著者名
Yoshimura, Aya
著者名
Honda, Takumi
e-Rad_Researcher
70363900
著者名
Wakimoto, Toshiyuki
言語
英語
キーワード
viridogrisein
antibiotic
biosynthesis
depsipeptide
streptogramin
self-resistant system
発行日
2024-01-18
出版者
The Pharmaceutical Society of Japan
日本薬学会
収録物名
Chemical and pharmaceutical bulletin
巻(号)
72(1)
ページ
80-85
抄録
Five new viridogriseins B-F were isolated from Streptomyces niveoruber, along with viridogrisein and griseoviridin which belong to streptogramin family antibiotics. A combination of liquid chromatographytandem mass spectrometry (LC-MS/MS) analysis and the advanced Marfey's method elucidated the structures of viridogriseins B-F, each featuring distinct constituent amino acids. Consistent with other streptogramin family antibiotics, these viridogrisein analogs exhibited potent antibacterial activity against Staphylococcus aureus. Furthermore, equimolar mixtures of each viridogrisein analog and griseoviridin inhibited the growth of S. aureus more potently than each analog treatment alone. Finally, an in vitro functional analysis of SgvY, encoded in the viridogrisein biosynthetic gene cluster, revealed that SgvY detoxifies viridogrisein against S. aureus by linearization. Considering that viridogrisein is not autotoxic to S. niveoruber, SgvY likely contributes to the self -resistance system against viridogrisein in S. niveoruber.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0009-2363
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1248/cpb.c23-00776