open access

https://hdl.handle.net/2115/92675

Syntheses and Biological Activities of Danicalipin A Derivatives

英語

structure-activity relationship

2023-06

Wiley-Blackwell

Chemistry and Biodiversity

20(6)

e202300400

Synthesis of three derivatives of danicalipin A, tetrachloride, trisulfate and a fluorescent probe was achieved through Wittig reaction strategy. Toxicity of the derivatives against brine shrimp (Artemia salina) as also investigated to provide useful information for the biological activity; i) less chloride derivative showed similar toxicity to danicalipin A, ii) the amphiphilic property, a characteristic feature of danicalipin A, was crucial because trisulfate considerably decreased the toxicity and iii) fluorescent derivative kept brine shrimp toxicity of danicalipin A.

学術雑誌論文

Accepted Manuscript

This is the peer reviewed version of the following article: Taiki Umezawa, Takeshi Maeda, Takuya Akiyama, Nurcahyo Iman Prakoso, Jakia Jerin Mehjabin, Tatsufumi Okino, Fuyuhiko Matsuda. Syntheses and Biological Activities of Danicalipin A Derivatives. Chemistry & Biodiversity: Volume 20, Issue 6. e202300400. June 2023, which has been published in final form at https://doi.org/10.1002/cbdv.202300400. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

1612-1872