open access

https://hdl.handle.net/2115/93090

Serum levels of vitamin D and periodontal inflammation in community-dwelling older Japanese adults : The Otassha Study

英語

vitamin D

2023-09

John Wiley & Sons

Journal of Clinical Periodontology

50(9)

1167-1175

Aim: To evaluate the association between vitamin D status and periodontal inflammation as determined by the periodontal inflamed surface area (PISA) in communitydwelling older adults. Materials and Methods: This cross-sectional study included 467 Japanese adults (mean age = 73.1 years) who underwent full-mouth periodontal examinations and measurements of serum levels of 25-hydroxyvitamin D (25(OH)D). We used linear regression and restricted cubic spline models to analyse the association between exposure (serum 25(OH)D) and outcome (PISA). Results: The linear regression model showed that, after adjusting for potential confounders, participants in the lowest quartile of serum 25(OH)D had 41.0 mm(2) more PISA (95% confidence interval [CI]: 4.6-77.5) than the reference group (the highest quartile of serum 25(OH)D). The spline model showed that the association between serum 25(OH)D and PISA was non-linear and restricted to the low 25(OH)D range. PISA initially sharply decreased as serum 25(OH)D increased, and then the decreasing trend slowed and plateaued. The inflection point with the minimum PISA value was a serum 25(OH)D level of 27.1 ng/mL, above which there was no decreasing trend in PISA with increasing serum 25(OH)D levels. Conclusions: Low vitamin D status had an L-shaped association with periodontal inflammation in this cohort of Japanese adults.

学術雑誌論文

Accepted Manuscript

This is the peer reviewed version of the following article: Iwasaki, M., Motokawa, K., Shirobe, M., Hayakawa, M., Ohara, Y., Motohashi, Y., Edahiro, A., Kawai, H., Fujiwara, Y., Sakata, Y., Ihara, K., Watanabe, Y., Obuchi, S., & Hirano, H. (2023). Serum levels of vitamin D and periodontal inflammation in community-dwelling older Japanese adults: The Otassha Study. Journal of Clinical Periodontology, 50(9), 1167–1175., which has been published in final form at https://doi.org/10.1111/jcpe.13834. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

0303-6979

AA00695586