Effect of chicken manure amendment on lead burden in mice : exposure to lead-spiked soil

Soe, Nyein Chan; Yohannes, Yared Beyene; Ohigashi, Takamitsu; Nakata, Hokuto; Tatsumi, Chikae; Uchida, Yoshitaka; Mufalo, Walubita; Ito, Mayumi; Sato, Tsutomu; Igarashi, Toshifumi; Ikenaka, Yoshinori; Ishizuka, Mayumi; Nakayama, Shouta M. M.

Effect of chicken manure amendment on lead burden in mice : exposure to lead-spiked soil

Soe, Nyein Chan; Yohannes, Yared Beyene; Ohigashi, Takamitsu et al.

Journal of Soils and Sediments, 2024

Permalink : https://hdl.handle.net/2115/94294

このアイテムのアクセス数:214件（2026-08-24 15:59 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/94294
タイトル	Effect of chicken manure amendment on lead burden in mice : exposure to lead-spiked soil
著者	Soe, Nyein Chan ; Yohannes, Yared Beyene ; Ohigashi, Takamitsu ; Nakata, Hokuto ; Tatsumi, Chikae ; Uchida, Yoshitaka ; Mufalo, Walubita ; Ito, Mayumi ; Sato, Tsutomu ; Igarashi, Toshifumi ; Ikenaka, Yoshinori ; Ishizuka, Mayumi ; Nakayama, Shouta M. M.
著者名 Soe, Nyein Chan
著者名 Yohannes, Yared Beyene
著者名 Ohigashi, Takamitsu
e-Rad_Researcher 60815273 著者名 Nakata, Hokuto
e-Rad_Researcher 30883417 著者名 Tatsumi, Chikae
e-Rad_Researcher 70705251 著者名 Uchida, Yoshitaka
著者名 Mufalo, Walubita
e-Rad_Researcher 10339690 著者名 Ito, Mayumi
e-Rad_Researcher 10313636 著者名 Sato, Tsutomu
e-Rad_Researcher 90301944 著者名 Igarashi, Toshifumi
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
e-Rad_Researcher 90647629 著者名 Nakayama, Shouta M. M.
言語	英語
キーワード	Remediation
	Chicken manure
	Lead-spiked soil
	Oxidative stress
	Apoptosis
発行日	2024-03-13
出版者	Springer
収録物名	Journal of Soils and Sediments
抄録	Purpose Adding organic soil amendments, like animal manure, can alleviate the mobility of lead (Pb). However, there is a scarcity of in vivo studies examining the impact of animal manure as a soil amendment on mammals. Methods Six C57BL/6 mice per group were raised for 30 and 98 days on soil containing 3000 mg Pb/kg. On Pb-spiked soil, chicken manure (40 t/ha) was applied as an immobilizer. Pb concentrations in the tissues were analyzed using ICP-MS after microwave digestion. RT-PCR was used to measure the mRNA expression of antioxidant and cell apoptosis genes in the liver, kidneys, and brain. Results When chicken manure was used as the immobilizer in Pb-spiked soil, Pb concentrations in the brain, kidneys, and lungs at day 30 were significantly different (p < 0.05) with reduction percentages of 28.58, 26.63, and 25.62, respectively. The brain, kidneys, liver, and bone, except for the lungs and trachea, also showed a similar reducing phenomenon on day 98, with percentages of 11.82, 4.63, 29.87, and 14.54, respectively. There was a significant difference in the levels of Nrf2, HMOX1, SOD1, CAT, BCL2, and Bax in the brain between Pb-exposed and remediated groups after 98 days of exposure. Conclusions This study highlights that the utilization of chicken manure reduced Pb accumulation in tissues (6.25-28.58% at 30 days and 4.63-29.87% at 98 days). This reduction in Pb accumulation subsequently alleviated the body burden by activating antioxidant genes in the brain, notably HMOX1, SOD1, and CAT.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11368-024-03769-y
PISSN	1439-0108
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s11368-024-03769-y