Radiotherapy with or without chemotherapy for locally advanced head and neck cancer in elderly patients: analysis of the Head and Neck Cancer Registry of Japan

Yasuda, Koichi; Uchinami, Yusuke; Kano, Satoshi; Taguchi, Jun; Kawakita, Daisuke; Kitayama, Megumi; Nishioka, Kentaro; Mori, Takashi; Koizumi, Fuki; Fujii, Yuri; Shimizu, Yasushi; Kobashi, Keiji; Yoshimoto, Seiichi; Nibu, Ken-ichi; Homma, Akihiro; Aoyama, Hidefumi

Radiotherapy with or without chemotherapy for locally advanced head and neck cancer in elderly patients: analysis of the Head and Neck Cancer Registry of Japan

Yasuda, Koichi; Uchinami, Yusuke; Kano, Satoshi et al.

International journal of clinical oncology, 2023, 29(3), 241-247

Permalink : https://hdl.handle.net/2115/94706

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アクセス権	open access
URI	https://hdl.handle.net/2115/94706
タイトル	Radiotherapy with or without chemotherapy for locally advanced head and neck cancer in elderly patients: analysis of the Head and Neck Cancer Registry of Japan
著者	Yasuda, Koichi ; Uchinami, Yusuke ; Kano, Satoshi ; Taguchi, Jun ; Kawakita, Daisuke ; Kitayama, Megumi ; Nishioka, Kentaro ; Mori, Takashi ; Koizumi, Fuki ; Fujii, Yuri ; Shimizu, Yasushi ; Kobashi, Keiji ; Yoshimoto, Seiichi ; Nibu, Ken-ichi ; Homma, Akihiro ; Aoyama, Hidefumi
e-Rad_Researcher 00431362 著者名 Yasuda, Koichi
著者名 Uchinami, Yusuke
著者名 Kano, Satoshi
著者名 Taguchi, Jun
著者名 Kawakita, Daisuke
著者名 Kitayama, Megumi
著者名 Nishioka, Kentaro
著者名 Mori, Takashi
著者名 Koizumi, Fuki
著者名 Fujii, Yuri
著者名 Shimizu, Yasushi
著者名 Kobashi, Keiji
著者名 Yoshimoto, Seiichi
著者名 Nibu, Ken-ichi
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
e-Rad_Researcher 80360915 著者名 Aoyama, Hidefumi
言語	英語
キーワード	Head and neck cancer
	Elderly
	Chemoradiotherapy
発行日	2023-12-29
出版者	Springer
収録物名	International journal of clinical oncology
巻(号)	29(3)
ページ	241-247
抄録	Background Whether concurrent chemotherapy with radiotherapy (CRT) is effective for elderly patients with head and neck cancer is a controversial topic. This study aimed to analyze the effectiveness of CRT vs. radiation therapy (RT) among elderly patients in Japan.Methods Data from the Head and Neck Cancer Registry of Japan were extracted and analyzed. Patients with locally advanced squamous cell carcinoma of the oropharynx, hypopharynx, or larynx who received definitive CRT or RT between 2011 and 2014 were included.Results CRT was administered to 78% of the 1057 patients aged >= 70 years and 67% of the 555 patients aged >= 75 years. For the patients aged >= 75 years, the overall survival (OS) rate was significantly better in the CRT group than in the RT group (P < 0.05), while the progression-free survival (PFS) rate was not significantly different (P > 0.05). The add-on effect of CRT was significantly poor in elderly patients (P < 0.05), and it was not a significant factor in the multivariate analysis for patients aged >= 75 years. After propensity score matching, there were no significant differences in the OS and PFS rates between the patients aged >= 70 years and those aged >= 75 years (all, P > 0.05).Conclusion Although aggressive CRT is administered to elderly patients in Japan, its effectiveness is uncertain. Further prospective randomized trials are needed to verify whether CRT is superior to RT alone for elderly patients.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10147-023-02450-7]
PISSN	1341-9625
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s10147-023-02450-7