The chest CT signs for pulmonary veno-occlusive disease correlate with pulmonary haemodynamics in systemic sclerosis

Moriya, Haruka; Kato, Masaru; Hisada, Ryo et al.

Rheumatology, 2024, 63(7), 1868-1873

Permalink : https://hdl.handle.net/2115/95811

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アクセス権
open access
URI
https://hdl.handle.net/2115/95811
タイトル
The chest CT signs for pulmonary veno-occlusive disease correlate with pulmonary haemodynamics in systemic sclerosis
著者
Moriya, Haruka ; Kato, Masaru ; Hisada, Ryo ; Ninagawa, Keita ; Tada, Maria ; Sakiyama, Kodai ; Yasuda, Mitsutaka ; Kono, Michihito ; Fujieda, Yuichiro ; Amengual, Olga ; Kikuchi, Yasuka ; Tsujino, Ichizo ; Sato, Takahiro ; Atsumi, Tatsuya
著者名
Moriya, Haruka
e-Rad_Researcher
10755896
著者名
Kato, Masaru
著者名
Hisada, Ryo
著者名
Ninagawa, Keita
著者名
Tada, Maria
著者名
Sakiyama, Kodai
著者名
Yasuda, Mitsutaka
e-Rad_Researcher
00835192
著者名
Kono, Michihito
e-Rad_Researcher
70790872
著者名
Fujieda, Yuichiro
著者名
Amengual, Olga
著者名
Kikuchi, Yasuka
e-Rad_Researcher
00344507
著者名
Tsujino, Ichizo
著者名
Sato, Takahiro
e-Rad_Researcher
20301905
著者名
Atsumi, Tatsuya
言語
英語
キーワード
Pulmonary arterial hypertension
SSc
Pulmonary veno-occlusive disease
Chest CT
発行日
2024-07
出版者
Oxford university press
収録物名
Rheumatology
巻(号)
63(7)
ページ
1868-1873
抄録
Objectives Pulmonary arterial hypertension associated with systemic sclerosis (PAH-SSc) sometimes accompanies pulmonary veno-occlusive disease (PVOD). We aimed to reveal the relationship between clinical signs of PVOD and severity of pulmonary vasculopathy in SSc. Methods This study included 52 consecutive SSc patients who had pulmonary haemodynamic abnormalities [mean pulmonary arterial pressure (mPAP) >20 mmHg, pulmonary vascular resistance >2 WU or pulmonary artery wedge pressure (PAWP) >15 mmHg]. A chest CT scan was evaluated in all patients. Patients were divided into two groups, the 0–1 group and the 2–3 group, according to the number of chest CT signs for PVOD, including mediastinal lymph node enlargement, thickened interlobular septal wall and ground glass opacity. Pulmonary haemodynamics, echocardiography and MRI-based cardiac function, pulmonary function and serum biomarkers were compared between the two groups. Results Mediastinal lymph node enlargement, thickened interlobular septal wall and ground glass opacity were observed in 11 (21%), 32 (62%) and 11 (21%) patients, respectively. The 2–3 group (n = 15) had higher mPAP (P = 0.02) but lower diffusing capacity of carbon monoxide (DLCO)/alveolar volume (P = 0.02) compared with the 0–1 group (n = 37). Other parameters, including PAWP, cardiac output, left ventricular ejection fraction, left atrial diameter, forced vital capacity, brain natriuretic peptide and Krebs von den Lunge-6 were not different between the two groups. Conclusions The CT signs for PVOD had a positive correlation with mPAP but a negative correlation with DLCO in SSc patients, indicating that PAH-SSc may reflect a spectrum of pulmonary vascular disease that ranges from the pulmonary artery to the vein.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
This is a pre-copyedited, author-produced version of an article accepted for publication in Rheumatology following peer review. The version of record Haruka Moriya, Masaru Kato, Ryo Hisada, Keita Ninagawa, Maria Tada, Kodai Sakiyama, Mitsutaka Yasuda, Michihito Kono, Yuichiro Fujieda, Olga Amengual, Yasuka Kikuchi, Ichizo Tsujino, Takahiro Sato, Tatsuya Atsumi, The chest CT signs for pulmonary veno-occlusive disease correlate with pulmonary haemodynamics in systemic sclerosis, Rheumatology, Volume 63, Issue 7, July 2024, Pages 1868–1873 is available online at: https://doi.org/10.1093/rheumatology/kead485.
PISSN
1462-0324
EISSN
1462-0332
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1093/rheumatology/kead485