open access

https://hdl.handle.net/2115/97368

Associations of sarcopenia and malnutrition with 30-day in-hospital morbidity and mortality after cardiac surgery

英語

Sarcopenia

2024-12-17

Oxford university press

European journal of cardio-thoracic surgery

67(1)

ezae456

OBJECTIVES Sarcopenia and malnutrition often occur simultaneously in adults with cardiovascular diseases. Our objective was to determine the associations of preoperative sarcopenia and malnutrition with major adverse cardiac and cerebral events (MACCE) after cardiac surgery METHODS We retrospectively analysed 154 consecutive patients who underwent elective cardiac surgery between January 2015 and June 2018 at two institutions in Japan. Sarcopenia and nutritional status were preoperatively assessed by bilateral psoas muscle volume index (PMVI) using CT scans and the prognostic nutritional index (PNI), respectively. RESULTS The median age in the total cohort was 69 years, and 43% were women. Within 30 days after surgery, 20 patients developed in-hospital MACCE and seven patients died of any cause. Low PMVI (<72.25 cm3/m2) and low PNI (<48.15) were each independent predictors of postoperative MACCE occurrence with odds ratios (95% confidence interval) of 3.58 (1.22–10.53) and 3.73 (1.25–11.09) when adjusted for age and sex, and 3.25 (1.07–9.87) and 3.27 (1.08–9.89) when adjusted for preoperative left ventricular ejection fraction, angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker, and anticoagulant. In addition, the combination of low PMVI and low PNI conferred the highest risk of in-hospital MACCE among the four groups (i.e. the low PMVI, low PNI, low PMVI + low PNI and neither low PMVI nor low PNI groups). CONCLUSIONS Preoperative low PMVI and low PNI were respectively associated with 30-day in-hospital MACCE occurrence after cardiac surgery. Notably, coexistence of these reductions further enhanced the risk of postoperative MACCE.

学術雑誌論文

Accepted Manuscript

This is a pre-copyedited, author-produced version of an article accepted for publication in European Journal of Cardio-Thoracic Surgery following peer review. The version of record Takahiro Abe, Tasuku Inao, Yasushige Shingu, Akira Yamada, Shingo Takada, Arata Fukushima, Noriko Oyama-Manabe, Isao Yokota, Satoru Wakasa, Shintaro Kinugawa, Takashi Yokota, Associations of sarcopenia and malnutrition with 30-day in-hospital morbidity and mortality after cardiac surgery, European Journal of Cardio-Thoracic Surgery, Volume 67, Issue 1, January 2025, ezae456 is available online at: https://doi.org/10.1093/ejcts/ezae456.

1010-7940