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線虫C. elegansの低温耐性・馴化における全身周回性の神経回路による腸の脂肪蓄積の制御
山城, 芹奈;寺西, 宏顕;本村, 晴佳;太田, 茜;久原, 篤
Permalink : http://hdl.handle.net/2115/89122
JaLCDOI : 10.14943/lowtemsci.81.19
KEYWORDS : 線虫;温度馴化;神経回路;神経回路;C. elegans;cold tolerance;temperature acclimation;neural circuit
Abstract
動物の寒冷適応戦略の解析モデルとして使われている線虫C. elegansの低温応答・低温耐性に関する最新の研究を紹介する．C. elegansは，そのエレガントな姿に引けを取らないほど古典的な遺伝学に力強い長所があり，それに加えて，最新の全脳イメージングや，個体が持つ302個の全ての神経細胞の単一ニューロントランスクリプトームデータベースなど，最先端の学術ソースを兼ね備える究極のモデル動物である．本稿では，C. elegansが示す低温耐性と温度馴化における，温度受容から低温耐性までの分子と組織のネットワーク機構に関する最新の知見を概説する．シンプルな動物の低温耐性から次々と見つかってきた，予期せぬ分子と組織を介した低温耐性の制御機構には，分野外の読者も興味を惹かれるであろう．
As a model for analyzing cold tolerance and acclimation strategies in animals, we introduce the latest research on cold response and cold tolerance in the nematode C. elegans. C. elegans is one of the ultimate model animals, combining the classic strengths of powerful genetics that are second to none in its elegant appearance, with the latest scientific resources, including whole brain imaging and a transcriptome database of all 302 single neurons in the animal. This paper outlines the recent study of the molecular and tissue networks underlying the cold tolerance and temperature acclimation of C. elegans. Even those the person outside the field will be fascinated by the unexpected molecular and tissue-mediated regulatory mechanisms of cold tolerance that have been discovered in a simple model.
As a model for analyzing cold tolerance and acclimation strategies in animals, we introduce the latest research on cold response and cold tolerance in the nematode C. elegans. C. elegans is one of the ultimate model animals, combining the classic strengths of powerful genetics that are second to none in its elegant appearance, with the latest scientific resources, including whole brain imaging and a transcriptome database of all 302 single neurons in the animal. This paper outlines the recent study of the molecular and tissue networks underlying the cold tolerance and temperature acclimation of C. elegans. Even those the person outside the field will be fascinated by the unexpected molecular and tissue-mediated regulatory mechanisms of cold tolerance that have been discovered in a simple model.
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