Japanese Journal of Veterinary Research;Volume 32, Number 3

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TISSUE AND BLOOD EOSINOPHILIA IN MAST CELL-DEFICIENT Sl/Sl^d MICE INFECTED WITH TRICHINELLA SPIRALIS

OKU, Yuzaburo;ITAYAMA, Hiroshi;KAMIYA, Masao;OHBAYASHI, Masashi

Permalink : http://hdl.handle.net/2115/2309
JaLCDOI : 10.14943/jjvr.32.3.165
KEYWORDS : eosinophilia;mast cell;Sl;Sl^d mice;Trichinella spiralis

Abstract

The influence of mast cell-deficiency on the gut, muscle and blood eosinophilias in Sl/Sl^d mice infected with Trichinella spiralis was examined. In mast cell-deficient Sl/Sl^d mice, eosinophilia in the peripheral blood, small intestine and muscles was observed in primary and tertiary infections. But the time courses of tissue eosinophilia in Sl/Sl^d mice and normal littermates were somewhat different. Although tissue eosinophilia was a partially mast cell-dependent phenomenon, the mast cell was not central to eosinophilia. Also, the mast cell did not appear to play a role in blood eosinophilia.

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