Japanese Journal of Veterinary Research;Volume 3, Number 1

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BIOCHEMICAL STUDIES ON THE INCREASE AND FORMATION OF ANTIBODIES WITH CHYMOPAPAIN IN VITRO : II. STUDIES ON THE INCREASE OF DIPHTHERIAL ANTITOXIC TITERS FROM THE TRYPSIN-DIGESTED ANTITOXIC GLOBULINS

ITO, Tokiya

Permalink : http://hdl.handle.net/2115/3282
JaLCDOI : 10.14943/jjvr.3.1.33

Abstract

The present data indicate that the fragmental diphtherial antitoxins produced with trypsin digestion from the large incomplete antitoxic molecules, those produced in horses at the initial stages of the diphtherial immunization, are not converted newly into small and complete antitoxic molecules in the incubation with oxidized chymopapain and toxin, by which those produced with pepsin digestion were converted into. It is considered that the fragments, produced with trypsin digestion, are not convenient to be converted into complete antitoxins by the incubating procedures with oxidized chymopapain and toxin. The fact suggests that the characteristic differentiation of the pepsin-digested globulins and trypsin-digested ones is due to the difference of the molecular fine structure of the two.

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