Japanese Journal of Veterinary Research;Volume 68 Number 1

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Pharmacokinetics and bioavailability of tildipirosin in goats using HPLC

Elazab, Sara Taha;Badawy, Marwa Elsaied

Permalink : http://hdl.handle.net/2115/76749
JaLCDOI : 10.14943/jjvr.68.1.1
KEYWORDS : Goat;HPLC;Pharmacokinetics;Tildipirosin

Abstract

The goal of this study was to assess the pharmacokinetic properties of tildipirosin in female goats (n=15) following single intravenous (IV) injection at 4mg/kg and subcutaneous (SC) administration at 2 and 4 mg/kg. There were no adverse effects noted after IV and SC administration. Plasma concentrations of tildipirosin were measured using high-performance liquid chromatography (HPLC). The pharmacokinetic parameters of tildipirosin were computed by the non-compartmental model with WinNonlin 4.1 software. After single SC injection of 2 and 4 mg/kg, the maximum plasma concentrations were 571.6 ± 39.22 and 720 ± 52.99 ng/ml achieved at 30 min, respectively. Moreover, the mean values for the elimination half-life (T1/2λz) were 75.34 ± 2.71and 94.76 ± 8.13 hr, and the AUC0-last values were 11.09 ± 1.64 and 19.59 ± 4.18 respectively. The absolute bioavailability of tildipirosin after 4mg/kg SC injection was 96.64%. Tildipirosin was widely distributed following 4 mg/kg IV injection with volume of distribution 24.69 ± 4.10 L/kg and the plasma clearance was 0.216 ± 0.029 L/hr/kg. Tildipirosin showed favorable pharmacokinetic features in goats with rapid absorption, high bioavailability, wide distribution and long persistence in the body. These findings provide a guidance for using tildipirosin in goats.

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