Driving and photo-regulation of myosin-actin motors at molecular and macroscopic levels by photo-responsive high energy molecules

Menezes, Halley M.; Islam, Md. Jahirul; Takahashi, Masayuki et al.

Organic & biomolecular chemistry, 2017, 15(42), 8894-8903

Permalink : https://hdl.handle.net/2115/71967

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/71967
タイトル
Driving and photo-regulation of myosin-actin motors at molecular and macroscopic levels by photo-responsive high energy molecules
著者
Menezes, Halley M. ; Islam, Md. Jahirul ; Takahashi, Masayuki ; Tamaoki, Nobuyuki
著者名
Menezes, Halley M.
著者名
Islam, Md. Jahirul
著者名
Takahashi, Masayuki
e-Rad_Researcher
00344218
著者名
Tamaoki, Nobuyuki
言語
英語
発行日
2017-11-14
出版者
Royal Society of Chemistry
収録物名
Organic & biomolecular chemistry
巻(号)
15(42)
ページ
8894-8903
抄録
We employed an azobenzene based non-nucleoside triphosphate, AzoTP, in a myosin-actin motile system and demonstrated its efficiency as an energy molecule to drive and photo-regulate the myosin-actin motile function at the macroscopic level along with an in vitro motility assay. The AzoTP in its trans state induced shortening of a glycerinated muscle fibre whilst a cis isomer had no significant effect. Direct photoirradiation of a cis-AzoTP infused muscle fibre induced shortening triggered by a locally photo-generated trans-AzoTP in the muscle fibre. Furthermore, we designed and synthesized three new derivatives of AzoTPs that served as substrates for myosin by driving and photo-regulating the myosin-actin motile function at the molecular as well as the macroscopic level with varied efficiencies.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
1477-0520
関連情報
PMID
28902195
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1039/c7ob01293d