Molecular, antigenic, and pathogenic characterization of H5N8 highly pathogenic avian influenza viruses isolated in the Democratic Republic of Congo in 2017

Twabela, T. Augustin; Okamatsu, Masatoshi; Tshilenge, Georges Mbuyi; Mpiana, Serge; Masumu, Justin; Lam Thanh Nguyen; Matsuno, Keita; Monne, Isabella; Zecchin, Bianca; Sakoda, Yoshihiro

Molecular, antigenic, and pathogenic characterization of H5N8 highly pathogenic avian influenza viruses isolated in the Democratic Republic of Congo in 2017

Twabela, T. Augustin; Okamatsu, Masatoshi; Tshilenge, Georges Mbuyi et al.

Archives of virology, 2019, 165(1), 87-96

Permalink : https://hdl.handle.net/2115/79728

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/79728
タイトル	Molecular, antigenic, and pathogenic characterization of H5N8 highly pathogenic avian influenza viruses isolated in the Democratic Republic of Congo in 2017
著者	Twabela, T. Augustin ; Okamatsu, Masatoshi ; Tshilenge, Georges Mbuyi ; Mpiana, Serge ; Masumu, Justin ; Lam Thanh Nguyen ; Matsuno, Keita ; Monne, Isabella ; Zecchin, Bianca ; Sakoda, Yoshihiro
著者名 Twabela, T. Augustin
e-Rad_Researcher 00507163 著者名 Okamatsu, Masatoshi
著者名 Tshilenge, Georges Mbuyi
著者名 Mpiana, Serge
著者名 Masumu, Justin
著者名 Lam Thanh Nguyen
e-Rad_Researcher 40753306 著者名 Matsuno, Keita
著者名 Monne, Isabella
著者名 Zecchin, Bianca
e-Rad_Researcher 40333637 著者名 Sakoda, Yoshihiro
言語	英語
発行日	2019-11-09
出版者	Springer
収録物名	Archives of virology
巻(号)	165(1)
ページ	87-96
抄録	In May 2017, high mortality of chickens and Muscovy ducks due to the H5N8 highly pathogenic avian influenza virus (HPAIV) was reported in the Democratic Republic of Congo (DR Congo). In this study, we assessed the molecular, antigenic, and pathogenic features in poultry of the H5N8 HPAIV from the 2017 Congolese outbreaks. Phylogenetic analysis of the eight viral gene segments revealed that all 12 DR Congo isolates clustered in clade 2.3.4.4B together with other H5N8 HPAIVs isolated in Africa and Eurasia, suggesting a possible common origin of these viruses. Antigenically, a slight difference was observed between the Congolese isolates and a representative virus from group C in the same clade. After intranasal inoculation with a representative DR Congo virus, high pathogenicity was observed in chickens and Muscovy ducks but not in Pekin ducks. Viral replication was higher in chickens than in Muscovy duck and Pekin duck organs; however, neurotropism was pronounced in Muscovy ducks. Our data confirmed the high pathogenicity of the DR Congo virus in chickens and Muscovy ducks, as observed in the field. National awareness and strengthening surveillance in the region are needed to better control HPAIVs.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in Archives of virology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00705-019-04456-x
PISSN	0304-8608
EISSN	1432-8798
NCID	AA00548901
関連情報	PMID 31707455
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00705-019-04456-x