Genital organ-associated lymphoid tissues arranged in a ring in the mucosa of cow vaginal vestibules

Chuluunbaatar, Tsolmon; Ichii, Osamu; Masum, Md Abdul; Namba, Takashi; Islam, Md Rashedul; Otani, Yuki; Elewa, Yaser Hosny Ali; Kon, Yasuhiro

Genital organ-associated lymphoid tissues arranged in a ring in the mucosa of cow vaginal vestibules

Chuluunbaatar, Tsolmon; Ichii, Osamu; Masum, Md Abdul et al.

Research in veterinary science, 2022, 145, 147-158

Permalink : https://hdl.handle.net/2115/90205

このアイテムのアクセス数:385件（2026-01-16 20:27 集計）

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Manuscript	pdf	4.09 MB	204
Supplementary file	pdf	22.6 KB	80	Supplementary material
Supplementary table 1	docx	19.5 KB	71	Supplemental Table 1
Supplementary table 2	docx	19.6 KB	64	Supplemental Table 2
Supplementary table 3	docx	21.6 KB	65	Supplemental Table 3

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/90205
タイトル	Genital organ-associated lymphoid tissues arranged in a ring in the mucosa of cow vaginal vestibules
著者	Chuluunbaatar, Tsolmon ; Ichii, Osamu ; Masum, Md Abdul ; Namba, Takashi ; Islam, Md Rashedul ; Otani, Yuki ; Elewa, Yaser Hosny Ali ; Kon, Yasuhiro
著者名 Chuluunbaatar, Tsolmon
著者名 Ichii, Osamu
著者名 Masum, Md Abdul
著者名 Namba, Takashi
著者名 Islam, Md Rashedul
著者名 Otani, Yuki
著者名 Elewa, Yaser Hosny Ali
e-Rad_Researcher 10178402 著者名 Kon, Yasuhiro
言語	英語
キーワード	Cow
	Genital organ associated lymphoid tissue
	Lymphoid ring
	Lymphatic follicle
	Diffuse lymphoid tissue
発行日	2022-07
出版者	Elsevier
収録物名	Research in veterinary science
巻(号)	145
ページ	147-158
抄録	Female reproductive tracts are equipped with local and mucosal immune systems; however, structural information remains unclear for farm animals. In this study, the mucosa-associated lymphoid tissue-like structures in cow reproductive tracts were described. Vaginal vestibule (VV) and external parts of the genital organ, including the clitoris and vulva, were morphologically analyzed. Whole-mount specimens revealed several hematoxylinpositive spots arranged in a ring in the mucosa. Histologically, these spots were aggregated immune cells and defined as genital organ-associated lymphoid tissues (GOALTs). GOALTs were composed of lymphatic follicles (LFs) or diffuse lymphoid tissues (DLTs) at different depths of lamina propria. LFs frequently contained germinal centers. Scattered lymphocytes occupied the border area between follicles and epithelium, whereas DLTs had indefinite shapes. GOALTs contained immune cells and high endothelial venules. B cells were dominant both in LFs and DLTs. Abundant collagenous fibers were stretched across VV lamina propria, whereas reticular fibers were primarily observed in the DLT rather than LF. The epithelium covering of GOALTs was partially or fully disrupted by the invasion of immune cells toward the VV lumen. These findings suggest GOALTs function as a "genital lymphoid ring" as in Waldeyer's pharyngeal ring and act as immunological gate systems in cow reproductive tracts.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0034-5288
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.rvsc.2022.02.011