Correlation between antibiotic use and resistance of gram-negative bacteria at a university hospital in Japan from 2013 to 2021 : a study using the Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system

Kagami, Keisuke; Ishiguro, Nobuhisa; Iwasaki, Sumio et al.

European Journal of Hospital Pharmacy, 2023, 32(1), 3-9

Permalink : https://hdl.handle.net/2115/92557

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/92557
タイトル
Correlation between antibiotic use and resistance of gram-negative bacteria at a university hospital in Japan from 2013 to 2021 : a study using the Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system
著者
Kagami, Keisuke ; Ishiguro, Nobuhisa ; Iwasaki, Sumio ; Taki, Keisuke ; Fukumoto, Tatsuya ; Hayasaka, Kasumi ; Oyamada, Reiko ; Watanabe, Tsubasa ; Nakakubo, Sho ; Niinuma, Yusuke ; Sugawara, Mitsuru ; Takekuma, Yoh
著者名
Kagami, Keisuke
e-Rad_Researcher
40168216
著者名
Ishiguro, Nobuhisa
著者名
Iwasaki, Sumio
著者名
Taki, Keisuke
著者名
Fukumoto, Tatsuya
著者名
Hayasaka, Kasumi
著者名
Oyamada, Reiko
著者名
Watanabe, Tsubasa
著者名
Nakakubo, Sho
著者名
Niinuma, Yusuke
著者名
Sugawara, Mitsuru
e-Rad_Researcher
00396293
著者名
Takekuma, Yoh
言語
英語
キーワード
J-SIPHE
surveillance
antibiotic use
antibiotic resistance
carbapenems
発行日
2023-07-12
出版者
BMJ Publishing Group
収録物名
European Journal of Hospital Pharmacy
巻(号)
32(1)
ページ
3-9
抄録
ObjectivesThe Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system aggregates information related to antimicrobial resistance (AMR) measures. We aimed to investigate the correlation between antibiotic use and AMR at a university hospital from 2013 to 2021 in a time series analysis using the J-SIPHE system. We also studied this correlation in each ward (inter-ward analysis). MethodsData on antibiotic use and resistance rates were collected from the J-SIPHE system, except for the resistance rate in each ward, which was calculated from the source data prepared for this system. ResultsPiperacillin/tazobactam use was positively correlated with piperacillin/tazobactam resistance in Escherichia coli and Klebsiella pneumoniae in the inter-ward analysis, and in Pseudomonas aeruginosa in both analyses. Carbapenem use was positively correlated with meropenem resistance in Enterobacter cloacae in the time series analysis and in P. aeruginosa in both analyses, and imipenem/cilastatin resistance in P. aeruginosa in inter-ward analysis. Quinolone use was positively correlated with levofloxacin resistance in E. coli in both analyses, and in K. pneumoniae in inter-ward analysis. ConclusionsThis is the first study to investigate the correlation between antibiotic use and AMR at a single hospital in time series and inter-ward analyses using the J-SIPHE system and data prepared for this system, suggesting that this system may be useful for promoting AMR measures.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
This article has been accepted for publication in [European journal of hospital pharmacy, 2023] following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/ejhpharm-2023-003797. © European Association of Hospital Pharmacists 2023. Reuse of this manuscript version (excluding any databases, tables, diagrams, photographs and other images or illustrative material included where a another copyright owner is identified) is permitted strictly pursuant to the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC-BY-NC 4.0) http://creativecommons.org
PISSN
2047-9956
EISSN
2047-9964
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1136/ejhpharm-2023-003797