Dyslipidemia as a novel risk for the development of symptomatic ossification of the posterior longitudinal ligament

Fukada, Shotaro; Endo, Tsutomu; Takahata, Masahiko; Kanayama, Masahiro; Koike, Yoshinao; Fujita, Ryo; Suzuki, Ryota; Murakami, Toshifumi; Hasegawa, Tomoka; Terkawi, Mohamad Alaa; Hashimoto, Tomoyuki; Yamada, Kastuhisa; Sudo, Hideki; Kadoya, Ken; Iwasaki, Norimasa

Dyslipidemia as a novel risk for the development of symptomatic ossification of the posterior longitudinal ligament

Fukada, Shotaro; Endo, Tsutomu; Takahata, Masahiko et al.

The spine journal, 2023, 23(9), 1287-1295

Permalink : https://hdl.handle.net/2115/93409

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/93409
タイトル	Dyslipidemia as a novel risk for the development of symptomatic ossification of the posterior longitudinal ligament
著者	Fukada, Shotaro ; Endo, Tsutomu ; Takahata, Masahiko ; Kanayama, Masahiro ; Koike, Yoshinao ; Fujita, Ryo ; Suzuki, Ryota ; Murakami, Toshifumi ; Hasegawa, Tomoka ; Terkawi, Mohamad Alaa ; Hashimoto, Tomoyuki ; Yamada, Kastuhisa ; Sudo, Hideki ; Kadoya, Ken ; Iwasaki, Norimasa
著者名 Fukada, Shotaro
e-Rad_Researcher 90805293 著者名 Endo, Tsutomu
e-Rad_Researcher 40374368 著者名 Takahata, Masahiko
著者名 Kanayama, Masahiro
著者名 Koike, Yoshinao
著者名 Fujita, Ryo
著者名 Suzuki, Ryota
著者名 Murakami, Toshifumi
著者名 Hasegawa, Tomoka
著者名 Terkawi, Mohamad Alaa
著者名 Hashimoto, Tomoyuki
著者名 Yamada, Kastuhisa
e-Rad_Researcher 30374367 著者名 Sudo, Hideki
e-Rad_Researcher 30374276 著者名 Kadoya, Ken
e-Rad_Researcher 30322803 著者名 Iwasaki, Norimasa
言語	英語
キーワード	Abnormal lipid metabolism
	Dyslipidemia
	Obesity
	Ossification of the posterior longitudinal ligament (OPLL)
	Symptomatic OPLL
	Visceral fat
	Whole-spine CT
発行日	2023-09
出版者	Elsevier
収録物名	The spine journal
巻(号)	23(9)
ページ	1287-1295
抄録	BACKGROUND CONTEXT Obesity and visceral fat have been implicated as potential factors in the pathogenesis of the ossification of the posterior longitudinal ligament (OPLL); the details of the factors involved in OPLL remain unclear. PURPOSE We aimed to determine the association between dyslipidemia and symptomatic OPLL. STUDY DESIGN Single institution cross-sectional study. PATIENT SAMPLE Data were collected from Japanese patients with OPLL (n=92) who underwent whole-spine computed tomography scanning. Control data (n=246) without any spinal ligament ossification were collected from 627 Japanese participants who underwent physical examination. OUTCOME MEASURES Baseline information and lipid parameters, including triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) from fasting blood samples were collected to assess the comorbidity of dyslipidemia. METHODS Patient data were collected from 2020 to 2022. Patients with dyslipidemia were defined as those who were taking medication for dyslipidemia and who met one of the following criteria: TG ≥150 mg/dL, LDL-C ≥140 mg/dL, and/or HDL-C <40 mg/dL. The factors associated with OPLL development were evaluated using multivariate logistic regression analysis. RESULTS The comorbidity of dyslipidemia in the OPLL group was more than twice that in the control group (71.7% and 35.4%, respectively). The mean body mass index (BMI) of the OPLL group was significantly higher than that of the control group (27.2 kg/m2 and 23.0 kg/m2). Multivariate logistic regression analysis revealed that dyslipidemia was associated with the development of OPLL (regression coefficient, 0.80; 95% confidence interval, 0.11–1.50). Additional risk factors included age, BMI, and diabetes mellitus. CONCLUSIONS We demonstrated a novel association between dyslipidemia and symptomatic OPLL development using serum data. This suggests that visceral fat obesity or abnormal lipid metabolism are associated with the mechanisms of onset and exacerbation of OPLL as well as focal mechanical irritation due to being overweight.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1529-9430
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.spinee.2023.05.005