open access

https://hdl.handle.net/2115/94313

Tough Hydroxyapatite Hydrogels Based on Bone-like Self-Regulatory Sacrificial Bond Formation

英語

2024-03-26

American Chemical Society

Chemistry of materials

36(6)

2944-2952

Learning from nature is a promising approach to achieving specific functions of synthetic materials. The high material functions, in turn, shed light on the fundamental mechanisms underlying the high performance of biological tissues. For instance, bone is an attractive metabolic tissue with fascinating capabilities from the perspective of both biochemical and biomechanical functionalities. Bone tissue exhibits exceptional mechanical performance as a skeleton, enabling to sustain the locomotion of mammals. In this study, we design coupled reactions for self-regulatory sacrificial bond formation in poly(acrylic acid) hydrogels by introducing biomineral hydroxyapatite (HAp) found in bones. We demonstrate that through five coupled reactions, HAp regulates the Ca2+ bridging to the acidic polymer and toughens the hydrogels in water by the sacrificial bonds effect. This work is expected not only to greatly contribute to the design of tough soft materials but also to give deep insights into the self-regulated bone-toughening mechanisms.

学術雑誌論文

Accepted Manuscript

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Chemistry of materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/articlesonrequest/AOR-IYDQTXIYAKDC7B37BJYD.

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