Japanese Journal of Veterinary Research;Volume 69 Number 1

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Cross-species reactivity of antibodies against Ixodes persulcatus ferritin 2 to Rhipicephalus microplus

Xavier, Marina Amaral;Konnai, Satoru;Parizi, Luís Fernando;Githaka, Naftaly Wang'ombe;Isezaki, Masayoshi;Goto, Shinya;Fujisawa, Sotaro;Yamada, Shinji;Okagawa, Tomohiro;Maekawa, Naoya;Logullo, Carlos;Vaz, Itabajara da Silva Jr;Murata, Shiro;Ohashi, Kazuhiko

Permalink : http://hdl.handle.net/2115/80621
JaLCDOI : 10.14943/jjvr.69.1.57
KEYWORDS : ferritin;tick;vaccine

Abstract

There are several studies that confirm the possibility of developing a vaccine against tick infestations. An immuno-bioinformatics approach was used to identify conserved antigenic regions between Ixodes persulcatus and Rhipicephalus microplus ferritin 2 (FER2) in order to compose a novel putative vaccine. In addition, R. microplus were fed on blood containing antibodies anti-recombinant FER2 from I. persulcatus (rIp-FER2). The results revealed that anti-ferritin antibodies led to a decrease in the engorgement weight of the R. microplus females. Conservation of the predicted antigenic regions in different tick species suggests that this protein could be useful to develop a vaccine for cross-species protection.

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