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Volume 69 Number 1 >

Cross-species reactivity of antibodies against Ixodes persulcatus ferritin 2 to Rhipicephalus microplus

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Title: Cross-species reactivity of antibodies against Ixodes persulcatus ferritin 2 to Rhipicephalus microplus
Authors: Xavier, Marina Amaral Browse this author
Konnai, Satoru Browse this author →KAKEN DB
Parizi, Luís Fernando Browse this author
Githaka, Naftaly Wang'ombe Browse this author
Isezaki, Masayoshi Browse this author
Goto, Shinya Browse this author
Fujisawa, Sotaro Browse this author
Yamada, Shinji Browse this author
Okagawa, Tomohiro Browse this author →KAKEN DB
Maekawa, Naoya Browse this author →KAKEN DB
Logullo, Carlos Browse this author
Vaz, Itabajara da Silva Jr Browse this author
Murata, Shiro Browse this author →KAKEN DB
Ohashi, Kazuhiko Browse this author →KAKEN DB
Keywords: ferritin
Issue Date: Feb-2021
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 69
Issue: 1
Start Page: 57
End Page: 65
Abstract: There are several studies that confirm the possibility of developing a vaccine against tick infestations. An immuno-bioinformatics approach was used to identify conserved antigenic regions between Ixodes persulcatus and Rhipicephalus microplus ferritin 2 (FER2) in order to compose a novel putative vaccine. In addition, R. microplus were fed on blood containing antibodies anti-recombinant FER2 from I. persulcatus (rIp-FER2). The results revealed that anti-ferritin antibodies led to a decrease in the engorgement weight of the R. microplus females. Conservation of the predicted antigenic regions in different tick species suggests that this protein could be useful to develop a vaccine for cross-species protection.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 69 Number 1

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