Clinical significance of anti-DNA/N-methyl-D-aspartate receptor 2 antibodies in de novo and post-steroid cases with neuropsychiatric systemic lupus erythematosus

Fujieda, Yuichiro; Mader, Simone; Jeganathan, Venkatesh; Arinuma, Yoshiyuki; Shimizu, Yuka; Kato, Masaru; Oku, Kenji; Minami, Akiko; Shimizu, Chikara; Yasuda, Shinsuke; Atsumi, Tatsuya

Clinical significance of anti-DNA/N-methyl-D-aspartate receptor 2 antibodies in de novo and post-steroid cases with neuropsychiatric systemic lupus erythematosus

Fujieda, Yuichiro; Mader, Simone; Jeganathan, Venkatesh et al.

International journal of rheumatic diseases, 2019, 22(3), 443-448

Permalink : https://hdl.handle.net/2115/76826

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/76826
タイトル	Clinical significance of anti-DNA/N-methyl-D-aspartate receptor 2 antibodies in de novo and post-steroid cases with neuropsychiatric systemic lupus erythematosus
著者	Fujieda, Yuichiro ; Mader, Simone ; Jeganathan, Venkatesh ; Arinuma, Yoshiyuki ; Shimizu, Yuka ; Kato, Masaru ; Oku, Kenji ; Minami, Akiko ; Shimizu, Chikara ; Yasuda, Shinsuke ; Atsumi, Tatsuya
e-Rad_Researcher 70790872 著者名 Fujieda, Yuichiro
著者名 Mader, Simone
著者名 Jeganathan, Venkatesh
著者名 Arinuma, Yoshiyuki
著者名 Shimizu, Yuka
著者名 Kato, Masaru
著者名 Oku, Kenji
著者名 Minami, Akiko
e-Rad_Researcher 00292029 著者名 Shimizu, Chikara
e-Rad_Researcher 00374231 著者名 Yasuda, Shinsuke
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
言語	英語
キーワード	anti-NR2 antibody
	neuropsychiatric systemic lupus erythematosus
	N-methyl D-aspartate receptors
	post-steroid neuropsychiatric manifestation
	systemic lupus erythematosus
発行日	2019-03
出版者	John Wiley & Sons
収録物名	International journal of rheumatic diseases
巻(号)	22(3)
ページ	443-448
抄録	Background Anti-DNA/N-methyl-D-aspartate receptor 2 (NR2) antibodies (anti-DNA/NR2 antibodies) are a subset of anti-DNA autoantibodies that cross-react with the extracellular domain of the GluN2A/GluN2B subunits of NR2. These antibodies induce apoptosis of hippocampus neurons and psychiatric disorder in mice and humans. Neuropsychiatric system lupus erythematosus (NPSLE) can develop after initiation of corticosteroids (post-steroid neuropsychiatric manifestation: PSNP) or before treatment (de novo NPSLE); however, pathophysiological differences between these subtypes remain unclear. The objective of this study was to clarify the prevalence of anti-DNA/NR2 antibodies in patients with NPSLE. Methods This study involved a cohort of patients with NPSLE admitted to our hospital. NPSLE patients were classified into two groups, de novo NPSLE and PSNP-SLE. Serum anti-DNA antibodies and anti-DNA/NR2 antibodies were measured by enzyme-linked immunosorbent assays. Results Serum samples were obtained from 24 patients with de novo NPSLE, 25 with PSNP-SLE and 76 healthy controls (HC). The level of anti-DNA/NR2 antibodies in patients with de novo NPSLE and PSNP-SLE were also higher than those in HC. Positive correlation between anti-DNA antibodies and anti-DNA/NR2 antibodies were found in PSNP-SLE, but was not significant in de novo NPSLE. Conclusion The levels of anti-DNA/NR2 antibodies in PSNP-SLE were similar to those in de novo NPSLE. Anti-DNA/NR2 antibodies in PSNP-SLE were suggested as a dominant subset of anti-DNA antibodies, indicating that anti-DNA/NR2 antibodies may be a predictive factor in PSNP-SLE.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer reviewed version of the following article: International journal of rheumatic diseases. 2019, 22(3), 443-448, which has been published in final form at https://doi.org/10.1111/1756-185X.13392. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
PISSN	1756-1841
関連情報	PMID 30358102
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1111/1756-185X.13392