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Multiple piscine vitellogenins : biomarkers of fish exposure to estrogenic endocrine disruptors in aquatic environments

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/10090

Title: Multiple piscine vitellogenins : biomarkers of fish exposure to estrogenic endocrine disruptors in aquatic environments
Authors: Hiramatsu, Naoshi Browse this author →KAKEN DB
Matsubara, Takahiro Browse this author
Fujita, Toshiaki Browse this author
Sullivan, Craig V. Browse this author
Hara, Akihiko5 Browse this author →KAKEN DB
Authors(alt): 原, 彰彦5
Issue Date: Apr-2006
Publisher: Springer
Journal Title: Marine Biology
Volume: 149
Issue: 1
Start Page: 35
End Page: 47
Publisher DOI: 10.1007/s00227-005-0214-z
Abstract: Vitellogenin (Vg), a major estrogen-inducible yolk precursor protein, has become an important biomarker for assessing the estrogenic potency of chemicals and the exposure of animals to estrogenic contaminants present in aquatic environments. These contaminants, which can disrupt functioning of the vertebrate neuroendocrine system, are known as endocrine disrupting chemicals (EDCs). In general, investigations of the significance of estrogenic EDCs have failed to keep pace with recent developments in our understanding of vitellogenesis in fishes. Recent gene cloning and immunobiochemical analyses have verified the general multiplicity of piscine Vg and led to exploration of the unique roles of yolk proteins derived from different forms of Vg in the processes of oogenesis and embryogenesis. The levels of circulating Vg proteins (or Vg gene transcripts) during oogenesis and their degree of induction by estrogens appear to vary among species and among different types of Vg within species. The kinetics of induction of distinct types of Vg by estrogens in fishes appears to depend on environmental factors (e.g., water temperature and photoperiod), life history stage, and the concentration and type of estrogenic compound. Consideration of these findings will contribute to development of Vg-based bioassays superior to those currently based on the outdated "single Vg" model.
Rights: The original publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/10090
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 原 彰彦

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