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Volume 51, Number 3-4 >

Comparison of virulence of various hantaviruses related to hemorrhagic fever with renal syndrome in newborn mouse model

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.51.3-4.143

Title: Comparison of virulence of various hantaviruses related to hemorrhagic fever with renal syndrome in newborn mouse model
Authors: Lokugamage, Kumari Browse this author
Kariwa, Hiroaki Browse this author →KAKEN DB
Lokugamage, Nandadeva Browse this author
Iwasa, Masahiro Browse this author
Hagiya, Tomohiro Browse this author
Araki, Koichi Browse this author
Tachi, Atsushi Browse this author
Mizutani, Tetsuya Browse this author
Yoshimatsu, Kumiko Browse this author
Arikawa, Jiro Browse this author
Iwasaki, Takuya Browse this author
Takashima, Ikuo Browse this author
Keywords: Amur
Far East
Hantavirus
mouse
virulence
Issue Date: Feb-2004
Publisher: The Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 51
Issue: 3-4
Start Page: 143
End Page: 149
Abstract: The virulence of hantaviruses that are antigenically related but have different genetic characteristics from the prototype of hantavirus, Hantaan (HTN) virus, was examined in newborn mice. The H5 and B78 strains of the Amur (AMR) genotype, the Bao14 strain of the Far East (FE) genotype, and the 76-118 strain of HTN virus were inoculated subcutaneously (1 focus-forming unit; FFU) into newborn mice. All of the AMR and FE genotype viruses inoculated mice were died by 16 days post-infection (dpi) and 21 dpi, respectively, while 50% of the HTN virus inoculated mice survived unti1 30 dpi. The AMR and FE genotype viruses inoculated mice had high viral titers in the lung (1.3x10⁶ to 1.3x10⁸ FFU/gram [g] tissue), brain(2.1x10⁷ to 1.2x10⁹ FFU/g tissue), and kidney(2.5x10⁵ to 1.6x10⁷ FFU/g tissue), and showed a detectable level of antibodies (titers 1:16-1:32) at 14 dpi. In contrast, the HTN virus infected mice had viruses only in the lungs at low titers (1.1-5.3x10⁵ FFU/g tissue). Observations of body-weight changes revealed that the AMR and FE genotype viruses inoculated mice had lower growth rates than the HTN virus inoculated mice. These data suggest that the AMR and FE genotype viruses are more virulent than the HTN virus in newborn mice.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/11312
Appears in Collections:Japanese Journal of Veterinary Research > Volume 51, Number 3-4

Submitter: 獣医学部図書室

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