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Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis
| Title: | Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis |
| Authors: | Ishikawa, Takahisa Browse this author | | Chen, Jian Browse this author | | Wang, Jingxin Browse this author | | Okada, Futoshi Browse this author | | Sugiyama, Toshiro Browse this author | | Kobayashi, Takahiko Browse this author | | Shindo, Masanobu Browse this author | | Higashino, Fumihiro Browse this author | | Katoh, Hiroyuki Browse this author | | Asaka, Masahiro Browse this author →KAKEN DB | | Kondo, Takeshi Browse this author →KAKEN DB | | Hosokawa, Masuo Browse this author | | Kobayashi, Masanobu Browse this author |
| Keywords: | pancreatic cancer | | hypoxia | | adrenomedullin | | angiogenesis | | adrenomedullin antagonist |
| Issue Date: | 27-Feb-2003 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Oncogene |
| Volume: | 22 |
| Issue: | 8 |
| Start Page: | 1238 |
| End Page: | 1242 |
| Publisher DOI: | 10.1038/sj.onc.1206207 |
| PMID: | 12606950 |
| Abstract: | Since it is reported that adrenomedullin (AM) upregulated by hypoxia inhibits hypoxic cell death, we examined the effects of AM antagonist (AM C-terminal fragment; AM(22-52)) on the growth of pancreatic cancer cells. We for the first time demonstrated that AM antagonist significantly reduced the in vivo growth of the pancreatic cancer cell line. Immunohistochemical analysis demonstrated that the mean diameter of blood vessels was significantly smaller in the tumor tissues treated with AM antagonist than in those treated with AM N-terminal fragment (AM(1-25)) and that the PCNA-labeling index was lower in the former than in the latter. Then we demonstrated that AM antagonist showed no effect on the in vitro growth of the pancreatic cancer cell line. These results showed that AM played an important role in the growth of pancreatic cancer cells in vivo, suggesting that AM antagonist might be a useful tool for treating pancreatic cancers. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/11316 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 小林 正伸
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