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Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis

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Title: Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis
Authors: Ishikawa, Takahisa Browse this author
Chen, Jian Browse this author
Wang, Jingxin Browse this author
Okada, Futoshi Browse this author
Sugiyama, Toshiro Browse this author
Kobayashi, Takahiko Browse this author
Shindo, Masanobu Browse this author
Higashino, Fumihiro Browse this author
Katoh, Hiroyuki Browse this author
Asaka, Masahiro Browse this author →KAKEN DB
Kondo, Takeshi Browse this author →KAKEN DB
Hosokawa, Masuo Browse this author
Kobayashi, Masanobu Browse this author
Keywords: pancreatic cancer
adrenomedullin antagonist
Issue Date: 27-Feb-2003
Publisher: Nature Publishing Group
Journal Title: Oncogene
Volume: 22
Issue: 8
Start Page: 1238
End Page: 1242
Publisher DOI: 10.1038/sj.onc.1206207
PMID: 12606950
Abstract: Since it is reported that adrenomedullin (AM) upregulated by hypoxia inhibits hypoxic cell death, we examined the effects of AM antagonist (AM C-terminal fragment; AM(22-52)) on the growth of pancreatic cancer cells. We for the first time demonstrated that AM antagonist significantly reduced the in vivo growth of the pancreatic cancer cell line. Immunohistochemical analysis demonstrated that the mean diameter of blood vessels was significantly smaller in the tumor tissues treated with AM antagonist than in those treated with AM N-terminal fragment (AM(1-25)) and that the PCNA-labeling index was lower in the former than in the latter. Then we demonstrated that AM antagonist showed no effect on the in vitro growth of the pancreatic cancer cell line. These results showed that AM played an important role in the growth of pancreatic cancer cells in vivo, suggesting that AM antagonist might be a useful tool for treating pancreatic cancers.
Type: article (author version)
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小林 正伸

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