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Influence of intravenous sedation with midazolam on Respiratory function and muscle activity inelderly and young patients

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Title: Influence of intravenous sedation with midazolam on Respiratory function and muscle activity inelderly and young patients
Authors: Fujisawa, Toshiaki Browse this author →KAKEN DB
Suzuki, Shinobu Browse this author
Kurozumi, Akihiro Browse this author
Kimura, Yukifumi Browse this author
Iida, Akira Browse this author
Fukushima, Kazuaki Browse this author
Keywords: Aged
Sedative
nonbarbiturate
Respiratory muscles
Hand strength
Issue Date: 1-Dec-2002
Publisher: Scientific
Journal Title: The Asian Journal of Oral and Maxillofacial Surgery
Volume: 14
Issue: 4
Start Page: 209
End Page: 214
Abstract: Objective: The purpose of this study was to investigate the optimal dosage of intravenous midazolam for sedation in elderly patients and compare the amount of depression of respiratory function and skeletal muscle activity after obtaining similar sedation levels in younger patients. Patients and Methods: Fifteen elderly patients older than 65 years (group E) and 15 patients younger than 55 years (group Y) underwent oral surgery or dental treatment with or without local anaesthesia after intravenous administration of midazolam. Results: The optimal dose for the elderly patients was 62% that for the younger patients. The duration of depression of arterial oxygen saturation and vital capacity was more prolonged among patients in group E than in those in group Y. The number of patients whose grip strength value recovered 15 and 30 minutes after administration of midazolam was significantly smaller for group E than for group Y. Conclusion: These results suggest that elderly people should be carefully treated with attention to the decrease in skeletal muscle activity, including respiratory and upper airway muscles, when receiving intravenous sedation with midazolam.
Rights: © Asian Journal of Oral and Maxillofacial Surgery
Relation: http://www.asianaoms.org/asianjournal.html
Type: article
URI: http://hdl.handle.net/2115/11367
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藤澤 俊明

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