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Potential Application of Poly(N-isopropylacrylamide) Gel Containing Polymeric Micelles to Drug Delivery Systems
| Title: | Potential Application of Poly(N-isopropylacrylamide) Gel Containing Polymeric Micelles to Drug Delivery Systems |
| Authors: | Yan, Hu1 Browse this author | | Tsujii, Kaoru Browse this author |
| Authors(alt): | 厳, 虎1 |
| Keywords: | Thermoresponsive gel | | Poly(N-isopropylacrylamide) (NIPA) gel | | Polymer surfactant | | Volume | | Drug delivery system |
| Issue Date: | 2005 |
| Publisher: | Elsevier B.V. |
| Journal Title: | Colloids and Surfaces B: Biointerfaces |
| Volume: | 46 |
| Issue: | 3 |
| Start Page: | 142 |
| End Page: | 146 |
| Publisher DOI: | 10.1016/j.colsurfb.2005.10.007 |
| PMID: | 16300934 |
| Abstract: | We have investigated rapidly thermo-responsive NIPA gel containing polymer surfactant PMDP (NIPA-PMDP gel) as a potential drug carrier using (+)-L-ascorbic acid as a model drug. In the NIPA-PMDP gel system micelles of polymer surfactant PMDP are trapped by the entanglement of polymer chains inside the gel networks. Therefore, in principle the gel system tightly stores targeted drug in the micelles and rapidly releases controlled amount of the drug by switching on-off of external stimuli such as temperature or infrared laser beam. In our investigation on release profile, the NIPA-PMDP gel system showed completely different releasing behavior from that of the conventional NIPA gel. The NIPA-PMDP gel released rapidly all loaded (+)-L-ascorbic acid above the phase transition temperature (ca. 34 ℃), while slowly released the corresponding amount of the drug below the temperature. In contrast, the conventional NIPA gel released more slowly limited amount of the drug above the phase transition temperature while similarly did to the NIPA-PMDP gel below the temperature. The release profile of the NIPA-PMDP gel seems to be governed by only kinetics of volume phase transition of the gel network but not by the hydrophobic domains of the micelles probably because of too hydrophilic nature of (+)-L-ascorbic acid. |
| Relation: | http://www.sciencedirect.com/science/journal/09277765 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/1381 |
| Appears in Collections: | 電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 厳 虎
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