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MSA-C is the predominant clinical phenotype of MSA in Japan : Analysis of 142 patients with probable MSA

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Title: MSA-C is the predominant clinical phenotype of MSA in Japan : Analysis of 142 patients with probable MSA
Authors: Yabe, Ichiro Browse this author →KAKEN DB
Soma, Hiroyuki Browse this author
Takei, Asako Browse this author
Fujiki, Naoto Browse this author
Yanagihara, Tetsuro Browse this author
Sasaki, Hidenao Browse this author
Keywords: Multiple system atrophy
Cerebellar ataxia
Autonomic failure
MR imaging
Diagnostic criteria
Issue Date: 15-Nov-2006
Publisher: Elsevier
Journal Title: Journal of the Neurological Sciences
Volume: 249
Issue: 2
Start Page: 115
End Page: 121
Publisher DOI: 10.1016/j.jns.2006.05.064
PMID: 16828805
Abstract: We investigated the clinical features and mode of disease progression in 142 patients with probable multiple system atrophy (MSA) according to the Consensus Criteria. The subjects included 84 men and 58 women with a mean age at onset of 58.2 ± 7.1 years (range: 38–79 years). Cerebellar signs were detected in 87.3% of these patients at the time of initial examination, and were found in 95.1% of them at latest follow-up. MSA-C was diagnosed in 83.8% of the patients at their first examination. Parkinsonism was initially detected in 28.9% of the patients, increasing to 51.4% at the latest follow-up. Among all of the subjects, only 16.2% were classified as having MSA-P on initial examination. At the latest follow-up, parkinsonian features had become predominant over cerebellar features in 24.6% of the 65 patients with MSA-C who were followed for more than 3 years. Although parkinsonism usually masked the signs of cerebellar involvement in MSA-C patients, none of the patients with MSA-P at an early stage showed predominance of cerebellar features at the latest follow-up. Parkinsonism is the predominant feature of MSA among Western patients, even at an early stage, but this study showed that cerebellar deficits are the main feature in Japanese patients. This difference of disease manifestations between ethnic groups suggests that genetic factors may influence the clinical phenotype of MSA.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 矢部 一郎

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