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MSA-C is the predominant clinical phenotype of MSA in Japan : Analysis of 142 patients with probable MSA
| Title: | MSA-C is the predominant clinical phenotype of MSA in Japan : Analysis of 142 patients with probable MSA |
| Authors: | Yabe, Ichiro Browse this author →KAKEN DB | | Soma, Hiroyuki Browse this author | | Takei, Asako Browse this author | | Fujiki, Naoto Browse this author | | Yanagihara, Tetsuro Browse this author | | Sasaki, Hidenao Browse this author |
| Keywords: | Multiple system atrophy | | Cerebellar ataxia | | Parkinsonism | | Autonomic failure | | MR imaging | | Diagnostic criteria |
| Issue Date: | 15-Nov-2006 |
| Publisher: | Elsevier |
| Journal Title: | Journal of the Neurological Sciences |
| Volume: | 249 |
| Issue: | 2 |
| Start Page: | 115 |
| End Page: | 121 |
| Publisher DOI: | 10.1016/j.jns.2006.05.064 |
| PMID: | 16828805 |
| Abstract: | We investigated the clinical features and mode of disease progression in 142 patients with probable multiple system atrophy (MSA) according to the Consensus Criteria. The subjects included 84 men and 58 women with a mean age at onset of 58.2 ± 7.1 years (range: 38–79 years). Cerebellar signs were detected in 87.3% of these patients at the time of initial examination, and were found in 95.1% of them at latest follow-up. MSA-C was diagnosed in 83.8% of the patients at their first examination. Parkinsonism was initially detected in 28.9% of the patients, increasing to 51.4% at the latest follow-up. Among all of the subjects, only 16.2% were classified as having MSA-P on initial examination. At the latest follow-up, parkinsonian features had become predominant over cerebellar features in 24.6% of the 65 patients with MSA-C who were followed for more than 3 years. Although parkinsonism usually masked the signs of cerebellar involvement in MSA-C patients, none of the patients with MSA-P at an early stage showed predominance of cerebellar features at the latest follow-up. Parkinsonism is the predominant feature of MSA among Western patients, even at an early stage, but this study showed that cerebellar deficits are the main feature in Japanese patients. This difference of disease manifestations between ethnic groups suggests that genetic factors may influence the clinical phenotype of MSA. |
| Relation: | http://www.sciencedirect.com/science/journal/0022510X |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/14449 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 矢部 一郎
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