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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Resection of lung metastasis from gallbladder carcinoma: immunohistochemistry of RCASI and CD8(+)T cells in primary and metastatic tumors
| Title: | Resection of lung metastasis from gallbladder carcinoma: immunohistochemistry of RCASI and CD8(+)T cells in primary and metastatic tumors |
| Authors: | Oshikiri, Taro1 Browse this author | | Morita, Takayuki Browse this author | | Fujita, Miyoshi Browse this author | | Miyasaka, Yuji Browse this author | | Senmaru, Naoto Browse this author | | Yamada, Hidehisa Browse this author | | Kaji, Naoto Browse this author | | Kondo, Satoshi8 Browse this author →KAKEN DB |
| Authors(alt): | 押切, 太郎1 | | 近藤, 哲8 |
| Keywords: | immunohistochemistry | | CD8 T cells | | thyroid transcription factor 1 | | RCAS1 |
| Issue Date: | 8-May-2006 |
| Publisher: | Elsevier Ireland |
| Journal Title: | Cancer letters |
| Volume: | 237 |
| Issue: | 1 |
| Start Page: | 115 |
| End Page: | 122 |
| Publisher DOI: | 10.1016/j.canlet.2005.05.050 |
| Abstract: | Advanced Gallbladder cancer has an extremely poor prognosis. We examined a patient with resectable gallbladder cancer with associated lung metastasis. A 64-year-old female patient, diagnosed with gallbladder cancer and a solitary benign lung tumor by imaging, was subjected to extensive cholecystectomy and extrahepatic bile duct resection. After one year, a follow-up CT indicated enlargement of the lung tumor; video-assisted right middle lobectomy was then performed. The lung tumor was diagnosed as a metastasis derived from the gallbladder cancer by pathology and immunohistochemistry. Expression of RCAS1, an independent unfavorable prognostic indicator in gallbladder cancer, was observed in both the gallbladder and lung tumors. However, infiltration of CD8+T cells was only seen in the lung metastatic tumor. She has remained free of any evidence of recurrence in the 10 months and 4 years after the first surgery. The results that metastasis is solitary and infiltrated by CD8+T cells correspond with the present clinical history. |
| Relation: | http://www.sciencedirect.com/science/journal/03043835 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/14474 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 押切 太郎
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