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In vitro demonstration of neural transmission of avian influenza A virus

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タイトル: In vitro demonstration of neural transmission of avian influenza A virus
著者: Matsuda, Kazuya 著作を一覧する
Shibata, Takuma 著作を一覧する
Sakoda, Yoshihiro 著作を一覧する
Kida, Hiroshi 著作を一覧する
Kimura, Takashi 著作を一覧する
Ochiai, Kenji 著作を一覧する
Umemura, Takashi 著作を一覧する
発行日: 2005年 4月
出版者: Society for General Microbiology
誌名: Journal of General Virology
巻: 86
号: 4
開始ページ: 1131
終了ページ: 1139
出版社 DOI: 10.1099/vir.0.80704-0
抄録: Neural involvement following infections of influenza viruses can be serious. The neural transport of influenza viruses from the periphery to the central nervous system has been indicated by using mouse models. However, no direct evidence for neuronal infection has been obtained in vitro and the mechanisms of neural transmission of influenza viruses have not been reported. In this study, the transneural transmission of a neurotropic influenza A virus was examined using compartmentalized cultures of neurons from mouse dorsal root ganglia, and the results were compared with those obtained using the pseudorabies virus, a virus with well-established neurotransmission. Both viruses reached the cell bodies of the neurons via the axons. This is the first report on axonal transport of influenza A virus in vitro. In addition, the role of the cytoskeleton (microtubules, microfilaments and intermediate filaments) in the neural transmission of influenza virus was investigated by conducting cytoskeletal perturbation experiments. The results indicated that the transport of avian influenza A virus in the neurons was independent of microtubule integrity but was dependent on the integrity of intermediate filaments, whereas pseudorabies virus needed both for neural spread.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 梅村 孝司


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