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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
Genome sequence analysis of the avian retrovirus causing so-called fowl glioma and the promoter activity of the long terminal repeat.
| Title: | Genome sequence analysis of the avian retrovirus causing so-called fowl glioma and the promoter activity of the long terminal repeat. |
| Authors: | Tomioka, Y. Browse this author | | Ochiai, K. Browse this author →KAKEN DB | | Ohashi, K. Browse this author | | Ono, E. Browse this author | | Toyoda, T. Browse this author →KAKEN DB | | Kimura, T. Browse this author →KAKEN DB | | Umemura, T. Browse this author →KAKEN DB |
| Issue Date: | Mar-2004 |
| Publisher: | Society for General Microbiology |
| Journal Title: | Journal of General Virology |
| Volume: | 85 |
| Issue: | 3 |
| Start Page: | 647 |
| End Page: | 652 |
| Publisher DOI: | 10.1099/vir.0.79778-0 |
| PMID: | 14993650 |
| Abstract: | So-called fowl glioma is a retroviral infectious disease caused by avian leukosis virus subgroup A (ALV-A). We determined the complete nucleotide sequence of the virus genome. The full-length sequence was consistent with a genetic organization typical of a replication-competent type C retrovirus lacking viral oncogenes. The coding sequences were well conserved with those of replication-competent viruses, but the 3' noncoding regions including LTR were most related to those of replication-defective sarcoma viruses. The U3 region of the LTR had a few deletions and several point mutations compared to that of other ALVs. The promoter activities of the LTRs of glioma-inducing ALV and ALV-A standard strain, RAV-1, were equivalent in chick embryo fibroblasts (CEF), while that of glioma-inducing ALV was significantly lower than that of RAV-1 in human astrocytic cells. These subtle differences of the promoter activity of the LTR may be related to the induction of glial neoplasm. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/14698 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 落合 謙爾
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