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Genome sequence analysis of the avian retrovirus causing so-called fowl glioma and the promoter activity of the long terminal repeat.

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タイトル: Genome sequence analysis of the avian retrovirus causing so-called fowl glioma and the promoter activity of the long terminal repeat.
著者: Tomioka, Y. 著作を一覧する
Ochiai, K. 著作を一覧する
Ohashi, K. 著作を一覧する
Ono, E. 著作を一覧する
Toyoda, T. 著作を一覧する
Kimura, T. 著作を一覧する
Umemura, T. 著作を一覧する
発行日: 2004年 3月
出版者: Society for General Microbiology
誌名: Journal of General Virology
巻: 85
号: 3
開始ページ: 647
終了ページ: 652
出版社 DOI: 10.1099/vir.0.79778-0
抄録: So-called fowl glioma is a retroviral infectious disease caused by avian leukosis virus subgroup A (ALV-A). We determined the complete nucleotide sequence of the virus genome. The full-length sequence was consistent with a genetic organization typical of a replication-competent type C retrovirus lacking viral oncogenes. The coding sequences were well conserved with those of replication-competent viruses, but the 3' noncoding regions including LTR were most related to those of replication-defective sarcoma viruses. The U3 region of the LTR had a few deletions and several point mutations compared to that of other ALVs. The promoter activities of the LTRs of glioma-inducing ALV and ALV-A standard strain, RAV-1, were equivalent in chick embryo fibroblasts (CEF), while that of glioma-inducing ALV was significantly lower than that of RAV-1 in human astrocytic cells. These subtle differences of the promoter activity of the LTR may be related to the induction of glial neoplasm.
資料タイプ: article
URI: http://hdl.handle.net/2115/14698
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 落合 謙爾

 

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