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Genome sequence analysis of the avian retrovirus causing so-called fowl glioma and the promoter activity of the long terminal repeat.

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/14698

Title: Genome sequence analysis of the avian retrovirus causing so-called fowl glioma and the promoter activity of the long terminal repeat.
Authors: Tomioka, Y. Browse this author
Ochiai, K. Browse this author →KAKEN DB
Ohashi, K. Browse this author
Ono, E. Browse this author
Toyoda, T. Browse this author →KAKEN DB
Kimura, T. Browse this author →KAKEN DB
Umemura, T. Browse this author →KAKEN DB
Issue Date: Mar-2004
Publisher: Society for General Microbiology
Journal Title: Journal of General Virology
Volume: 85
Issue: 3
Start Page: 647
End Page: 652
Publisher DOI: 10.1099/vir.0.79778-0
PMID: 14993650
Abstract: So-called fowl glioma is a retroviral infectious disease caused by avian leukosis virus subgroup A (ALV-A). We determined the complete nucleotide sequence of the virus genome. The full-length sequence was consistent with a genetic organization typical of a replication-competent type C retrovirus lacking viral oncogenes. The coding sequences were well conserved with those of replication-competent viruses, but the 3' noncoding regions including LTR were most related to those of replication-defective sarcoma viruses. The U3 region of the LTR had a few deletions and several point mutations compared to that of other ALVs. The promoter activities of the LTRs of glioma-inducing ALV and ALV-A standard strain, RAV-1, were equivalent in chick embryo fibroblasts (CEF), while that of glioma-inducing ALV was significantly lower than that of RAV-1 in human astrocytic cells. These subtle differences of the promoter activity of the LTR may be related to the induction of glial neoplasm.
Type: article
URI: http://hdl.handle.net/2115/14698
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 落合 謙爾

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