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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
A synthetic peptide from a heptad repeat region of herpesvirus glycoprotein B inhibits virus replication
| Title: | A synthetic peptide from a heptad repeat region of herpesvirus glycoprotein B inhibits virus replication |
| Authors: | Okazaki, Katsunori Browse this author →KAKEN DB | | Kida, Hiroshi Browse this author →KAKEN DB |
| Issue Date: | 2004 |
| Publisher: | Society for General Microbiology |
| Journal Title: | Journal of General Virology |
| Volume: | 85 |
| Issue: | 8 |
| Start Page: | 2131 |
| End Page: | 2137 |
| Publisher DOI: | 10.1099/vir.0.80051-0 |
| PMID: | 15269351 |
| Abstract: | Glycoprotein B (gB) is the most conserved glycoprotein of herpesviruses and plays important roles in virus infectivity. Two intervening heptad repeat (HR) sequences were found in the C-terminal half of all herpesvirus gBs analysed. A synthetic peptide derived from the HR region (aa 477–510) of bovine herpesvirus type 1 (BoHV-1) gB was studied for its ability to inhibit virus replication. The peptide interfered with cell-to-cell spread and consistently inhibited replication of BoHV-1, with a 50 % effective concentration value (EC50) of 5 µM. Inhibition of replication was obtained not only with herpesviruses including pseudorabies virus and herpes simplex virus type 1 but also partly with Newcastle disease virus. Possible mechanisms of membrane fusion inhibition by the peptide are discussed. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/14703 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 岡崎 克則
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