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A synthetic peptide from a heptad repeat region of herpesvirus glycoprotein B inhibits virus replication

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Title: A synthetic peptide from a heptad repeat region of herpesvirus glycoprotein B inhibits virus replication
Authors: Okazaki, Katsunori Browse this author →KAKEN DB
Kida, Hiroshi Browse this author →KAKEN DB
Issue Date: 2004
Publisher: Society for General Microbiology
Journal Title: Journal of General Virology
Volume: 85
Issue: 8
Start Page: 2131
End Page: 2137
Publisher DOI: 10.1099/vir.0.80051-0
PMID: 15269351
Abstract: Glycoprotein B (gB) is the most conserved glycoprotein of herpesviruses and plays important roles in virus infectivity. Two intervening heptad repeat (HR) sequences were found in the C-terminal half of all herpesvirus gBs analysed. A synthetic peptide derived from the HR region (aa 477–510) of bovine herpesvirus type 1 (BoHV-1) gB was studied for its ability to inhibit virus replication. The peptide interfered with cell-to-cell spread and consistently inhibited replication of BoHV-1, with a 50 % effective concentration value (EC50) of 5 µM. Inhibition of replication was obtained not only with herpesviruses including pseudorabies virus and herpes simplex virus type 1 but also partly with Newcastle disease virus. Possible mechanisms of membrane fusion inhibition by the peptide are discussed.
Type: article
URI: http://hdl.handle.net/2115/14703
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岡崎 克則

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