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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Life Science / Faculty of Advanced Life Science >
Peer-reviewed Journal Articles, etc >
Fractionation of a silk fibroin hydrolysate and its protective function of hydrogen peroxide toxicity
| Title: | Fractionation of a silk fibroin hydrolysate and its protective function of hydrogen peroxide toxicity |
| Authors: | Yeo, Joo-Hong Browse this author | | Lee, Kwang-Gill Browse this author | | Kweon, Hae-Yong Browse this author | | Woo, Soon-Ok Browse this author | | Han, Sang-Mi Browse this author | | Kim, Sung-Su Browse this author | | Demura, Makoto Browse this author →KAKEN DB |
| Keywords: | biocompatibility | | fibers | | high performance liquid chromatography (HPLC) | | peptides | | proteins |
| Issue Date: | 28-Jul-2006 |
| Publisher: | John Wiley & Sons, Inc. |
| Journal Title: | Journal of Applied Polymer Science |
| Volume: | 102 |
| Issue: | 1 |
| Start Page: | 772 |
| End Page: | 776 |
| Publisher DOI: | 10.1002/app.23740 |
| Abstract: | Fractionated components of Bombyx mori silk fibroin, which were hydrolyzed with protease, were prepared with a preparative-recycling high-performance-liquid-chromatography system to evaluate the protective effects of molecular-weight-controlled B. mori silk fibroin components on H2O2-injured neuronal cells. Three major fractions, having molecular weights less than about 1500, were first collected with the recycling techniques. The highest protective effect of the molecular-weight-controlled B. mori silk fibroin components on H2O2-injured neuronal cells was obtained when a fraction with a molecular weight of approximately 1400 was used. This protective effect of the silk fibroin hydrolysate on H2O2-injured neuronal cells was suggested to correlate with the contents of aromatic amino acids such as tyrosine and phenylalanine. |
| Rights: | Copyright © 2006 John Wiley & Sons, Inc., Journal of Applied Polymer Science, Volume 102, Issue 1, Pages 772-776 |
| Relation: | http://www.interscience.wiley.com/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/14705 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 出村 誠
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