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Fractionation of a silk fibroin hydrolysate and its protective function of hydrogen peroxide toxicity

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/14705

Title: Fractionation of a silk fibroin hydrolysate and its protective function of hydrogen peroxide toxicity
Authors: Yeo, Joo-Hong Browse this author
Lee, Kwang-Gill Browse this author
Kweon, Hae-Yong Browse this author
Woo, Soon-Ok Browse this author
Han, Sang-Mi Browse this author
Kim, Sung-Su Browse this author
Demura, Makoto Browse this author →KAKEN DB
Keywords: biocompatibility
fibers
high performance liquid chromatography (HPLC)
peptides
proteins
Issue Date: 28-Jul-2006
Publisher: John Wiley & Sons, Inc.
Journal Title: Journal of Applied Polymer Science
Volume: 102
Issue: 1
Start Page: 772
End Page: 776
Publisher DOI: 10.1002/app.23740
Abstract: Fractionated components of Bombyx mori silk fibroin, which were hydrolyzed with protease, were prepared with a preparative-recycling high-performance-liquid-chromatography system to evaluate the protective effects of molecular-weight-controlled B. mori silk fibroin components on H2O2-injured neuronal cells. Three major fractions, having molecular weights less than about 1500, were first collected with the recycling techniques. The highest protective effect of the molecular-weight-controlled B. mori silk fibroin components on H2O2-injured neuronal cells was obtained when a fraction with a molecular weight of approximately 1400 was used. This protective effect of the silk fibroin hydrolysate on H2O2-injured neuronal cells was suggested to correlate with the contents of aromatic amino acids such as tyrosine and phenylalanine.
Rights: Copyright © 2006 John Wiley & Sons, Inc., Journal of Applied Polymer Science, Volume 102, Issue 1, Pages 772-776
Relation: http://www.interscience.wiley.com/
Type: article (author version)
URI: http://hdl.handle.net/2115/14705
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 出村 誠

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