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Fractionation of a silk fibroin hydrolysate and its protective function of hydrogen peroxide toxicity

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タイトル: Fractionation of a silk fibroin hydrolysate and its protective function of hydrogen peroxide toxicity
著者: Yeo, Joo-Hong 著作を一覧する
Lee, Kwang-Gill 著作を一覧する
Kweon, Hae-Yong 著作を一覧する
Woo, Soon-Ok 著作を一覧する
Han, Sang-Mi 著作を一覧する
Kim, Sung-Su 著作を一覧する
Demura, Makoto 著作を一覧する
キーワード: biocompatibility
fibers
high performance liquid chromatography (HPLC)
peptides
proteins
発行日: 2006年 7月28日
出版者: John Wiley & Sons, Inc.
誌名: Journal of Applied Polymer Science
巻: 102
号: 1
開始ページ: 772
終了ページ: 776
出版社 DOI: 10.1002/app.23740
抄録: Fractionated components of Bombyx mori silk fibroin, which were hydrolyzed with protease, were prepared with a preparative-recycling high-performance-liquid-chromatography system to evaluate the protective effects of molecular-weight-controlled B. mori silk fibroin components on H2O2-injured neuronal cells. Three major fractions, having molecular weights less than about 1500, were first collected with the recycling techniques. The highest protective effect of the molecular-weight-controlled B. mori silk fibroin components on H2O2-injured neuronal cells was obtained when a fraction with a molecular weight of approximately 1400 was used. This protective effect of the silk fibroin hydrolysate on H2O2-injured neuronal cells was suggested to correlate with the contents of aromatic amino acids such as tyrosine and phenylalanine.
Rights: Copyright © 2006 John Wiley & Sons, Inc., Journal of Applied Polymer Science, Volume 102, Issue 1, Pages 772-776
Relation (URI): http://www.interscience.wiley.com/
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/14705
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 出村 誠

 

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