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PDGF isoforms induce and maintain anagen phase of murine hair follicles

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タイトル: PDGF isoforms induce and maintain anagen phase of murine hair follicles
著者: Tomita, Y. 著作を一覧する
Akiyama, M. 著作を一覧する
Shimizu, H. 著作を一覧する
キーワード: Hair cycle
Hair growth
発行日: 2006年 8月
出版者: Elsevier Ireland
誌名: Journal of Dermatological Science
巻: 43
号: 2
開始ページ: 105
終了ページ: 115
出版社 DOI: 10.1016/j.jdermsci.2006.03.012
抄録: Background : It is known that platelet-derived growth factor (PDGF) receptors are expressed in hair follicle (HF) epithelium. Objectives : The aim of the present study was to clarify the effects of PDGF-AA and -BB on the cyclic growth of HFs. Methods : PDGF-AA or -BB was injected into the dorsal skin of C3H mice during the second telogen phase once daily for five consecutive days, or PDGF-AA or -BB dissolved in hyaluronic acid was injected only once. In order to confirm the effects of different PDGF isoforms, anti-PDGF-AA antibody or anti-PDGF-BB antibody was injected just after each injection of PDGF-AA or -BB. In addition, anti-PDGF antibodies were injected into the skin of C3H mice during the second anagen phase once daily for 5 days. We studied expression of signaling molecules in the skin where anagen phase had been induced by PDGF injection by real-time RT-PCR. Results : Both PDGF-AA and -BB injection experiments immediately induced the anagen phase of the hair growth cycle at the injection sites. The induction of anagen was interfered by anti-PDGF antibody treatment. Real-time RT-PCR using extracted RNA from the PDGF injected sites of skin samples showed upregulated expression of HF differentiation-related key signaling molecules, Sonic hedgehog (Shh), Lef-1 and Wnt5a. Conclusions : These results indicate that both PDGF-AA and -BB are involved in the induction and maintenance of the anagen phase in the mouse hair cycle. Local application of PDGF-AA and -BB might therefore prove to be an effective treatment option for alopecia associated with early catagen induction and elongated telogen phase.
Relation (URI):
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 秋山 真志


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