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Expression of vascular endothelial growth factor and angiogenesis in patellar tendon grafts in the early phase after anterior cruciate ligament reconstruction.

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/14725

Title: Expression of vascular endothelial growth factor and angiogenesis in patellar tendon grafts in the early phase after anterior cruciate ligament reconstruction.
Authors: Yoshikawa, T. Browse this author
Tohyama, H. Browse this author
Enomoto, H. Browse this author
Matsumoto, H. Browse this author
Toyama, Y. Browse this author
Yasuda, K. Browse this author →KAKEN DB
Keywords: Anterior cruciate ligament reconstruction
Fibroblasts
Patellar tendon
Tendon graft
Vascular endothelial growth factor (VEGF)
Issue Date: Sep-2006
Publisher: Springer
Journal Title: Knee Surgery Sports Traumatology Arthroscopy
Volume: 14
Issue: 9
Start Page: 804
End Page: 810
Publisher DOI: 10.1007/s00167-006-0051-8
PMID: 16534655
Abstract: The aim of this study was to clarify vascular endothelial growth factor (VEGF) expression and angiogenesis in the patellar tendon (PT) autograft in the early phase after anterior cruciate ligament (ACL) reconstruction using a rabbit model. The right knees of 30 Japanese white rabbits underwent ACL reconstruction using the medial third of the PT complex. We evaluated the grafted tendon at 1, 2, 3, 4, and 8 weeks after ACL reconstruction by immunohistology for proliferating cell nuclear antigen, VEGF, and CD31, which is a marker for vascular endothelial cells. At week 1 , few cells were observed at the midsubstance of the grafted tendon. A number of proliferating cells were observed at the surface area of the PT graft 2 weeks after graft transplantation, while no vessel formation was observed in the graft at the same time. VEGF was highly expressed 2–3 weeks postoperatively. Vessel formation in the PT graft increased with time from 3 to 8 weeks after ACL reconstruction. The rates of proliferating cells and VEGF-expressing cells decreased with time from 3 to 8 weeks. This study has suggested that VEGF is involved in the graft remodeling process particularly at the early phase after ACL reconstruction.
Rights: The original publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/14725
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 遠山 晴一

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