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Pork peptone stimulates cholecystokinin secretion from enteroendocrine cells and suppresses appetite in rats.

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Title: Pork peptone stimulates cholecystokinin secretion from enteroendocrine cells and suppresses appetite in rats.
Authors: SUFIAN, MKNB Browse this author
HIRA, Tohru Browse this author
MIYASHITA, Kyoko Browse this author
NISHI, Takashi Browse this author
ASANO, Kozo Browse this author →KAKEN DB
HARA, Hiroshi Browse this author →KAKEN DB
Keywords: cholecystokinin
pork peptone
brush-border membrane
food intake
STC-1 cells
Issue Date: Aug-2006
Publisher: Japan Science and Technology Information Aggregator, Electronic
Journal Title: Bioscience Biotechnology and Biochemistry
Volume: 70
Issue: 8
Start Page: 1869
End Page: 1874
Publisher DOI: 10.1271/bbb.60046
PMID: 16926499
Abstract: We found that soybean β-conglycinin peptone (BconP) suppresses food intake through cholecystokinin (CCK) release from enteroendocrine cells in association with binding of the peptone to rat small intestinal brush border membrane (BBM). The aim of the present study was to find new appetite suppressing peptides. Peptones from chicken, pork, beef, beef liver, and egg white were examined for activities to bind with rat BBM, CCK-release from enteroendocrine cell line STC-1, and induce satiety in rats. Chicken and pork peptone (ChickP and PorkP) bound to BBM with highest ability as evaluated with a surface plasmon biosensor. PorkP and ChickP released CCK in higher amounts than BconP from STC-1 cells dose-dependently, with highest stimulation by PorkP. An orogastric preload of PorkP, but not ChickP, suppressed food intake similarly to BconP, dose-dependently. These results suggest that PorkP interacts directly with the small intestinal CCK cells to release CCK, and that it suppresses appetite in rats.
Type: article
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 原 博

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