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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Pork peptone stimulates cholecystokinin secretion from enteroendocrine cells and suppresses appetite in rats.
| Title: | Pork peptone stimulates cholecystokinin secretion from enteroendocrine cells and suppresses appetite in rats. |
| Authors: | SUFIAN, MKNB Browse this author | | HIRA, Tohru Browse this author | | MIYASHITA, Kyoko Browse this author | | NISHI, Takashi Browse this author | | ASANO, Kozo Browse this author →KAKEN DB | | HARA, Hiroshi Browse this author →KAKEN DB |
| Keywords: | cholecystokinin | | pork peptone | | brush-border membrane | | food intake | | STC-1 cells |
| Issue Date: | Aug-2006 |
| Publisher: | Japan Science and Technology Information Aggregator, Electronic |
| Journal Title: | Bioscience Biotechnology and Biochemistry |
| Volume: | 70 |
| Issue: | 8 |
| Start Page: | 1869 |
| End Page: | 1874 |
| Publisher DOI: | 10.1271/bbb.60046 |
| PMID: | 16926499 |
| Abstract: | We found that soybean β-conglycinin peptone (BconP) suppresses food intake through cholecystokinin (CCK) release from enteroendocrine cells in association with binding of the peptone to rat small intestinal brush border membrane (BBM). The aim of the present study was to find new appetite suppressing peptides. Peptones from chicken, pork, beef, beef liver, and egg white were examined for activities to bind with rat BBM, CCK-release from enteroendocrine cell line STC-1, and induce satiety in rats. Chicken and pork peptone (ChickP and PorkP) bound to BBM with highest ability as evaluated with a surface plasmon biosensor. PorkP and ChickP released CCK in higher amounts than BconP from STC-1 cells dose-dependently, with highest stimulation by PorkP. An orogastric preload of PorkP, but not ChickP, suppressed food intake similarly to BconP, dose-dependently. These results suggest that PorkP interacts directly with the small intestinal CCK cells to release CCK, and that it suppresses appetite in rats. |
| Relation: | http://www.jstage.jst.go.jp/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/14736 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 原 博
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