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Effects of difructose anhydride III (DFA III) administration on bile acids and growth of DFA III-assimilating bacterium Ruminococcus productus on rat intestine.

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Title: Effects of difructose anhydride III (DFA III) administration on bile acids and growth of DFA III-assimilating bacterium Ruminococcus productus on rat intestine.
Authors: Minamida, Kimiko Browse this author
Kaneko, Maki Browse this author
Ohashi, Midori Browse this author
Sujaya I., Nengah Browse this author
Sone, Teruo Browse this author
Wada, Masaru Browse this author
Yokota, Atsushi Browse this author
Hara, Hiroshi Browse this author
Asano, Kozo Browse this author →KAKEN DB
Tomita, Fusao Browse this author
Keywords: difructose anhydride III (DFAIII)
real-time PCR
Ruminococcus productus
bile acids
Issue Date: Jun-2005
Publisher: 日本生物工学会
Journal Title: Journal of Bioscience and Bioengineering
Volume: 99
Issue: 6
Start Page: 548
End Page: 554
Publisher DOI: 10.1263/jbb.99.548
PMID: 16233830
Abstract: The growth of DFA III-assimilating bacteria in the intestines of rats fed 3% DFA III for 2 weeks was examined. Sixty-four percent of the DFA III intake had been assimilated on day 3 of ingestion, and almost all of the DFA III was assimilated at the end of the experiment. The DFA III-assimilating bacterium, Ruminococcus productus, in DFA III-fed rats was in the stationary state of the 8th power of 10– the 9th power of 10 cells/g dry feces within a week from the 6th power of 10 cells/g dry feces on day 1 of DFA III ingestion. The number of R. productus cells was associated with the amount of DFA III excreted in the feces. The acetic acid produced from DFA III by R. productus lowered the cecal pH to 5.8. In control-fed rats and DFA III-fed rats, 94% of secondary bile acids and 94% of primary bile acids, respectively, were accounted for in the total bile acids analyzed. DFA III ingestion increased the ratio of primary bile acids and changed the composition of fecal bile acids. In conclusion, R. productus assimilated DFA III, produced short chain fatty acids, and the cecal pH was lowered. The acidification of rat intestine perhaps inhibited secondary bile acid formation and decreased the ratio of secondary bile acids. Therefore, it is expected that DFA III may prevent colorectal cancer and be a new prebiotic candidate.
Relation: http://www.sbj.or.jp/
Type: article (author version)
URI: http://hdl.handle.net/2115/14821
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 冨田 房男

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