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Strain and age-related changes in the localization of intestinal CD161+ natural killer cells and CD8+ intraepithelial lymphocytes along the longitudinal crypt axis in inbred rats.

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Title: Strain and age-related changes in the localization of intestinal CD161+ natural killer cells and CD8+ intraepithelial lymphocytes along the longitudinal crypt axis in inbred rats.
Authors: Xu, Hong Browse this author
Imanishi, Syunsuke Browse this author
Yamada, Kazuhiko Browse this author
Hara, Hiroshi Browse this author
Ishizuka, Satoshi Browse this author
Keywords: intraepithelial lymphocytes
CD161+ NK cells
ageing
intestine
Issue Date: Mar-2005
Publisher: 日本農芸化学会
Journal Title: Bioscience Biotechnology and Biochemistry
Volume: 69
Issue: 3
Start Page: 567
End Page: 574
Publisher DOI: 10.1271/bbb.69.567
PMID: 15784986
Abstract: Using a cell position approach, this study indicates that the frequency of CD161+ natural killer (NK) cells in the epithelia of DA rats was greater than that of WKAH and F344 rats. We further divided the epithelia into proliferating and differentiated regions according to the localization of BrdU-incorporated cells. Comparison between the different regions indicates that a majority of CD161+ NK cells were located in the proliferating region. With age, a decline in the number of CD161+ NK cells and CD8+ intraepithelial lymphocytes (IELs) was observed in the distal colon, especially in the proliferating region of all three strains. Taken together with our previous report that DA rats have far stronger resistance in the colon to preneoplastic lesion than do other strains, these results indicate that CD161+ NK cells play an important role in immune-surveillance at the bottom of the crypt.
Relation: http://www.jstage.jst.go.jp/
Type: article
URI: http://hdl.handle.net/2115/14831
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石塚 敏

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