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Isolation of tryptophan as an inhibitor of ovalbumin permeation and analysis of its suppressive effect on oral sensitization.

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Title: Isolation of tryptophan as an inhibitor of ovalbumin permeation and analysis of its suppressive effect on oral sensitization.
Authors: Watanabe, Jun Browse this author
Fukumoto, Kyoko Browse this author
Fukushi, Eri Browse this author
Sonoyama, Kei Browse this author →KAKEN DB
Kawabata, Jun Browse this author →KAKEN DB
Keywords: allergen absorption
tryptophan
Caco-2 cells
ovalbumin
Issue Date: Jan-2004
Publisher: 日本農芸化学会
Journal Title: Bioscience Biotechnology and Biochemistry
Volume: 68
Issue: 1
Start Page: 59
End Page: 65
Publisher DOI: 10.1271/bbb.68.59
PMID: 14745164
Abstract: Tryptophan was isolated from rat feces as an active compound against ovalbumin permeation in an in vitro Caco-2 cell model. Tryptophan dose-dependently inhibited ovalbumin permeation with accompanying increase in transepithelial electric resistance, and its inhibitory activity reached a plateau at 10 mM. Brown Norway rats were sensitized by intragastric administration of ovalbumin together with or without tryptophan. Antibody levels specific to ovalbumin in the sera and proliferative responses of spleen mononuclear cells to ovalbumin were significantly lower in rats administered ovalbumin plus tryptophan than those administered ovalbumin alone. These results suggest that tryptophan suppresses oral sensitization to ovalbumin, probably via suppression of ovalbumin absorption from the intestinal tract.
Type: article
URI: http://hdl.handle.net/2115/14848
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 園山 慶

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