Activin A induces phosphorylation of Smad2 but not complex formation of Smad2 with Smad4 in human colon cancer cell line HT-29


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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/14850

Title:	Activin A induces phosphorylation of Smad2 but not complex formation of Smad2 with Smad4 in human colon cancer cell line HT-29
Authors:	Pholnukulkit, Pimara Browse this author
	Sonoyama, Kei Browse this author →KAKEN DB
	Kawabata, Jun Browse this author →KAKEN DB
Keywords:	activin A
	Smad2
	Smad4
	colon cancer
	HT-29
Issue Date:	Sep-2003
Publisher:	日本農芸化学会
Journal Title:	Bioscience Biotechnology and Biochemistry
Volume:	67
Issue:	9
Start Page:	2042
End Page:	2044
Publisher DOI:	10.1271/bbb.67.2042
PMID:	14520001
Abstract:	Western blotting coupled with immunoprecipitation showed that activin A treatment induced phosphorylation of Smad2 but not complex formation of Smad2/4 in human colon cancer-derived HT-29 cells. Because HT-29 cells expressed neither Smad4 mRNA nor Smad4 protein, it is suggested that deletion of Smad4 leads to a defect of formation of Smad2/4 complex upon activin A stimulation in HT-29 cells.
Relation:	http://www.jstage.jst.go.jp/
Type:	article
URI:	http://hdl.handle.net/2115/14850
Appears in Collections:	農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 園山慶

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