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Activin A induces phosphorylation of Smad2 but not complex formation of Smad2 with Smad4 in human colon cancer cell line HT-29

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/14850

Title: Activin A induces phosphorylation of Smad2 but not complex formation of Smad2 with Smad4 in human colon cancer cell line HT-29
Authors: Pholnukulkit, Pimara Browse this author
Sonoyama, Kei Browse this author →KAKEN DB
Kawabata, Jun Browse this author →KAKEN DB
Keywords: activin A
Smad2
Smad4
colon cancer
HT-29
Issue Date: Sep-2003
Publisher: 日本農芸化学会
Journal Title: Bioscience Biotechnology and Biochemistry
Volume: 67
Issue: 9
Start Page: 2042
End Page: 2044
Publisher DOI: 10.1271/bbb.67.2042
PMID: 14520001
Abstract: Western blotting coupled with immunoprecipitation showed that activin A treatment induced phosphorylation of Smad2 but not complex formation of Smad2/4 in human colon cancer-derived HT-29 cells. Because HT-29 cells expressed neither Smad4 mRNA nor Smad4 protein, it is suggested that deletion of Smad4 leads to a defect of formation of Smad2/4 complex upon activin A stimulation in HT-29 cells.
Relation: http://www.jstage.jst.go.jp/
Type: article
URI: http://hdl.handle.net/2115/14850
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 園山 慶

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