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Long-Term Outcome After Resection of Non-small Cell Lung Carcinoma Complicated by Pneumoconiosis.

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Title: Long-Term Outcome After Resection of Non-small Cell Lung Carcinoma Complicated by Pneumoconiosis.
Authors: Ebihara, Yuma Browse this author
Makino, Yutaka Browse this author
Miyamoto, Masaki Browse this author
Hashimoto, Masahito Browse this author
Kondo, Satoshi Browse this author →KAKEN DB
Keywords: Pneumoconiosis
Non-small cell lung cancer
Prognosis
Issue Date: Oct-2006
Publisher: Springer
Journal Title: Surgery Today
Volume: 36
Issue: 10
Start Page: 869
End Page: 873
Publisher DOI: 10.1007/s00595-006-3264-z
PMID: 16998679
Abstract: Purpose Lung cancer resection in patients with respiratory complications is associated with a high surgical risk and the operative indications are usually serious. Consequently, the long-term results are unclear. We aimed to clarify the validity of surgery for non-small cell lung cancer (NSCLC) in patients with pneumoconiosis. Methods We reviewed the clinical and pathological data of 122 patients undergoing resection of NSCLC with pneumoconiosis (n = 34: group A) or without pneumoconiosis (n = 88: group B) to assess treatment outcomes and prognostic factors. Results Among the treatment factors, intraoperative blood loss was significantly greater in group A (723.2 ± 647.3 ml) than in group B (466.4 ± 450.7 ml) (P = 0.0067), although the operative times (207 ± 103.4 min vs 196.1 ± 53.5 min, respectively) and postoperative drainage period (8.3 ± 4.2 days vs 8.5 ± 5.7 days, respectively) did not differ significantly between the two groups (P = 0.9466 and P = 0.6355, respectively). Among the postoperative complications, the incidence of hemorrhage was significantly higher in group A (29.4%) than in group B (7.9%) (P = 0.0022). The 5-year survival rates did not differ significantly between the two groups, (45.9% and 55.7% for groups A and B respectively) (P = 0.9424). Conclusions The coexistence of pneumoconiosis does not adversely affect postoperative survival or the treatment of NSCLC, although it is associated with increased intraoperative blood loss and postoperative hemorrhage. Thus, if precautions are taken to minimize hemorrhage, surgery cannot be excluded as a treatment option for NSCLC in patients with pneumoconiosis.
Rights: The original publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/14867
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 近藤 哲

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