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Tumor necrosis factor-alpha genetic polymorphism may contribute to progression of bovine leukemia virus-infection

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Title: Tumor necrosis factor-alpha genetic polymorphism may contribute to progression of bovine leukemia virus-infection
Authors: Konnai, Satoru Browse this author →KAKEN DB
Usui, Tatsufumi Browse this author
Ikeda, Manabu Browse this author
Kohara, Junko Browse this author
Hirata, Toh-ichi Browse this author
Okada, Kosuke Browse this author
Ohashi, Kazuhiko Browse this author →KAKEN DB
Onuma, Misao Browse this author →KAKEN DB
Keywords: BLV
TNF-alpha
Polymorphism
Promoter
Disease progression
Issue Date: Jul-2006
Publisher: Elsevier
Journal Title: Microbes and Infection
Volume: 8
Issue: 8
Start Page: 2163
End Page: 2171
Publisher DOI: 10.1016/j.micinf.2006.04.017
PMID: 16839795
Abstract: In a previous report, we had indicated that in a sheep model, the expression of tumor necrosis factor (TNF)-α was closely associated with disease progression in sheep experimentally infected with bovine leukemia virus (BLV). However, individual variabilities are observed in these responses in BLV-infected animals. To attempt to identify genetic factors promoting the progression to BLV-induced lymphoma, we endeavored to determine whether there are any polymorphisms in the TNF-α gene among 291 individuals and whether this would affect the level of TNF-α expression and concomitant progression of BLV-induced disease or increase in the provirus load in the carriers. We found that the frequency of the TNF-α −824G allele, which has been associated with low transcription activity of the promoter/predicted enhancer region of the bovine TNF-α gene, was higher in individuals with BLV-induced lymphoma than in asymptomatic carrier individuals. In addition, we observed a tendency for increased BLV-provirus load in cattle with TNF-α −824G/G homozygote compared to TNF-α −824A/A homozygote or TNF-α −824A/G. These data suggest that the observed polymorphism in the promoter region of TNF-α gene could at least in part contribute to the progression of lymphoma in BLV-infection.
Relation: http://www.sciencedirect.com/science/journal/12864579
Type: article (author version)
URI: http://hdl.handle.net/2115/15426
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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