|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
Tumor necrosis factor-alpha genetic polymorphism may contribute to progression of bovine leukemia virus-infection
| Title: | Tumor necrosis factor-alpha genetic polymorphism may contribute to progression of bovine leukemia virus-infection |
| Authors: | Konnai, Satoru Browse this author →KAKEN DB | | Usui, Tatsufumi Browse this author | | Ikeda, Manabu Browse this author | | Kohara, Junko Browse this author | | Hirata, Toh-ichi Browse this author | | Okada, Kosuke Browse this author | | Ohashi, Kazuhiko Browse this author →KAKEN DB | | Onuma, Misao Browse this author →KAKEN DB |
| Keywords: | BLV | | TNF-alpha | | Polymorphism | | Promoter | | Disease progression |
| Issue Date: | Jul-2006 |
| Publisher: | Elsevier |
| Journal Title: | Microbes and Infection |
| Volume: | 8 |
| Issue: | 8 |
| Start Page: | 2163 |
| End Page: | 2171 |
| Publisher DOI: | 10.1016/j.micinf.2006.04.017 |
| PMID: | 16839795 |
| Abstract: | In a previous report, we had indicated that in a sheep model, the expression of tumor necrosis factor (TNF)-α was closely associated with disease progression in sheep experimentally infected with bovine leukemia virus (BLV). However, individual variabilities are observed in these responses in BLV-infected animals. To attempt to identify genetic factors promoting the progression to BLV-induced lymphoma, we endeavored to determine whether there are any polymorphisms in the TNF-α gene among 291 individuals and whether this would affect the level of TNF-α expression and concomitant progression of BLV-induced disease or increase in the provirus load in the carriers. We found that the frequency of the TNF-α −824G allele, which has been associated with low transcription activity of the promoter/predicted enhancer region of the bovine TNF-α gene, was higher in individuals with BLV-induced lymphoma than in asymptomatic carrier individuals. In addition, we observed a tendency for increased BLV-provirus load in cattle with TNF-α −824G/G homozygote compared to TNF-α −824A/A homozygote or TNF-α −824A/G. These data suggest that the observed polymorphism in the promoter region of TNF-α gene could at least in part contribute to the progression of lymphoma in BLV-infection. |
| Relation: | http://www.sciencedirect.com/science/journal/12864579 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/15426 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 今内 覚
|
