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Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma.

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タイトル: Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma.
著者: Kase, Satoru 著作を一覧する
Saito, Wataru 著作を一覧する
Yoshida, Kazuhiko 著作を一覧する
Namba, Kenichi 著作を一覧する
Osaki, Mitsuhiko 著作を一覧する
Ohgami, Kazuhiro 著作を一覧する
Shiratori, Kenji 著作を一覧する
Kitaichi, Nobuyoshi 著作を一覧する
Adachi, Hironobu 著作を一覧する
Ito, Hisao 著作を一覧する
Ohno, Shigeaki 著作を一覧する
キーワード: choroid
dThdPase
glaucoma
histopathology
melanoma
発行日: 2005年 9月
出版者: Blackwell Publishing, Inc.
誌名: Pathology International
巻: 55
号: 9
開始ページ: 569
終了ページ: 573
出版社 DOI: 10.1111/j.1440-1827.2005.01870.x
抄録: Reported herein is a case of 62-year-old man who complained of blurred vision and ocular pain in his right eye. The patient was diagnosed with choroidal melanoma complicated by neovascular glaucoma (NVG) and total retinal detachment, and he underwent enucleation of the eye. The isolated tumor was 2.5 × 2.5 cm in size. It was accompanied by intratumoral calcification, and consisted of epithelioid and spindle melanoma cells. There were a variety of microvessels in the stroma of the iris. The expression of thymidine phosphorylase (dThdPase), an angiogenic factor, was examined immunohistochemically. Cytoplasmic immunoreactivity for dThdPase was more prominent in the epithelioid cells than in spindle tumor cells. Another case of choroidal melanoma without NVG had less marked immunoreactivity. These results suggest that the production of dThdPase by melanoma cells correlates with the pathogenesis of NVG.
Rights: The definitive version is available at www.blackwell-synergy.com
関連URI: http://www.blackwell-synergy.com
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/15822
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 加瀬 諭

 

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