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Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma.

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Title: Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma.
Authors: Kase, Satoru Browse this author →KAKEN DB
Saito, Wataru Browse this author →KAKEN DB
Yoshida, Kazuhiko Browse this author →KAKEN DB
Namba, Kenichi Browse this author →KAKEN DB
Osaki, Mitsuhiko Browse this author
Ohgami, Kazuhiro Browse this author →KAKEN DB
Shiratori, Kenji Browse this author
Kitaichi, Nobuyoshi Browse this author →KAKEN DB
Adachi, Hironobu Browse this author
Ito, Hisao Browse this author
Ohno, Shigeaki Browse this author →KAKEN DB
Keywords: choroid
Issue Date: Sep-2005
Publisher: Blackwell Publishing, Inc.
Journal Title: Pathology International
Volume: 55
Issue: 9
Start Page: 569
End Page: 573
Publisher DOI: 10.1111/j.1440-1827.2005.01870.x
PMID: 16143032
Abstract: Reported herein is a case of 62-year-old man who complained of blurred vision and ocular pain in his right eye. The patient was diagnosed with choroidal melanoma complicated by neovascular glaucoma (NVG) and total retinal detachment, and he underwent enucleation of the eye. The isolated tumor was 2.5 × 2.5 cm in size. It was accompanied by intratumoral calcification, and consisted of epithelioid and spindle melanoma cells. There were a variety of microvessels in the stroma of the iris. The expression of thymidine phosphorylase (dThdPase), an angiogenic factor, was examined immunohistochemically. Cytoplasmic immunoreactivity for dThdPase was more prominent in the epithelioid cells than in spindle tumor cells. Another case of choroidal melanoma without NVG had less marked immunoreactivity. These results suggest that the production of dThdPase by melanoma cells correlates with the pathogenesis of NVG.
Rights: The definitive version is available at
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加瀬 諭

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