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Dietary branched-chain amino acids suppress the expression of pancreatic amylase mRNA in rats.

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Title: Dietary branched-chain amino acids suppress the expression of pancreatic amylase mRNA in rats.
Authors: Hashimoto, Naoto Browse this author
Hara, Hiroshi Browse this author →KAKEN DB
Keywords: pancreatic amylase
dietary branched-chain amino acids
dietary carbohydrate
Issue Date: May-2004
Publisher: Japan Society for Bioscience, Biotechnology, and Agrochemistry
Journal Title: Bioscience Biotechnology and Biochemistry
Volume: 68
Issue: 5
Start Page: 1067
End Page: 1072
Publisher DOI: 10.1271/bbb.68.1067
PMID: 15170111
Abstract: Regulators for pancreatic amylase were examined. Rats were fed ad libitum a 20% amino acid (AA) mixture diet (Con), a 60% AA diet (HA), a branched-chain amino acid (BCAA)-rich diet (BC), or a diet supplemented with AA other than BCAA (OA) for 7 d, or fed the Con, HA, BC diets or diets supplemented with individual BCAA. Activity and mRNA levels of pancreatic amylase in the BC and HA groups were lower than those in the Con and OA groups. Leucine and isoleucine contributed to these effects of the BC diet. The mRNA levels correlated with individual pancreatic BCAA concentrations but not with plasma insulin level. In conclusion, dietary BCAA, especially leucine and isoleucine, may reduce amylase mRNA and activity in rats.
Type: article
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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