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Intestinal absorption and metabolism of a soluble flavonoid, alphaG-rutin, in portal cannulated rats.

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Title: Intestinal absorption and metabolism of a soluble flavonoid, alphaG-rutin, in portal cannulated rats.
Authors: Matsumoto, Megumi Browse this author
Chiji, Hideyuki Browse this author
Hara, Hiroshi Browse this author →KAKEN DB
Keywords: Flavonoid
net absorption
portal cannula
Ussing chamber
Issue Date: Oct-2005
Publisher: Taylor & Francis
Journal Title: Free Radical Research
Volume: 39
Issue: 10
Start Page: 1139
End Page: 1146
Publisher DOI: 10.1080/10715760500264670
PMID: 16298739
Abstract: A highly soluble quercetin glycoside, αG-rutin, is a glucose adduct of insoluble rutin, and intestinal absorption and metabolism of αG-rutin has not been known. We investigated the intestinal absorption and metabolism of αG-rutin by using portal and duodenal cannulated rats and the isolated rat intestinal mucosa. After a duodenal instillation of αG-rutin (150 μmol), intact αG-rutin, rutin and quercetin were appeared in the portal blood and these concentrations were similarly increased at 15 min. Portal quercetin reached a peak value at 60 min, and the value was higher than those of αG-rutin and rutin at that time. Quercetin-conjugates were also increased 30 min after the instillation. The remaining of αG-rutin metabolites, mainly rutin, in the intestine were 58% of instilled αG-rutin after 150 min. In the experiment by using the isolated mucosa of the jejunum, ileum and cecum, αG-rutin and rutin, but not quercetin, appeared in the serosal sides of all segments, and they were increased linearly from 10 to 100 mmol/l of mucosal αG-rutin. We also showed portal injected αG-rutin was very rapidly cleared from the blood, and appeared a large amount of conjugates. In conclusion, a soluble flavonoid-glycoside, αG-rutin, was absorbed as glycosides into the portal blood. A part of αG-rutin was hydrolyzed to rutin, but not to aglycone, through the intestine.
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Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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