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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Intestinal absorption and metabolism of a soluble flavonoid, alphaG-rutin, in portal cannulated rats.
| Title: | Intestinal absorption and metabolism of a soluble flavonoid, alphaG-rutin, in portal cannulated rats. |
| Authors: | Matsumoto, Megumi Browse this author | | Chiji, Hideyuki Browse this author | | Hara, Hiroshi Browse this author →KAKEN DB |
| Keywords: | Flavonoid | | net absorption | | metabolism | | portal cannula | | Ussing chamber | | rat |
| Issue Date: | Oct-2005 |
| Publisher: | Taylor & Francis |
| Journal Title: | Free Radical Research |
| Volume: | 39 |
| Issue: | 10 |
| Start Page: | 1139 |
| End Page: | 1146 |
| Publisher DOI: | 10.1080/10715760500264670 |
| PMID: | 16298739 |
| Abstract: | A highly soluble quercetin glycoside, αG-rutin, is a glucose adduct of insoluble rutin, and intestinal absorption and metabolism of αG-rutin has not been known. We investigated the intestinal absorption and metabolism of αG-rutin by using portal and duodenal cannulated rats and the isolated rat intestinal mucosa. After a duodenal instillation of αG-rutin (150 μmol), intact αG-rutin, rutin and quercetin were appeared in the portal blood and these concentrations were similarly increased at 15 min. Portal quercetin reached a peak value at 60 min, and the value was higher than those of αG-rutin and rutin at that time. Quercetin-conjugates were also increased 30 min after the instillation. The remaining of αG-rutin metabolites, mainly rutin, in the intestine were 58% of instilled αG-rutin after 150 min. In the experiment by using the isolated mucosa of the jejunum, ileum and cecum, αG-rutin and rutin, but not quercetin, appeared in the serosal sides of all segments, and they were increased linearly from 10 to 100 mmol/l of mucosal αG-rutin. We also showed portal injected αG-rutin was very rapidly cleared from the blood, and appeared a large amount of conjugates. In conclusion, a soluble flavonoid-glycoside, αG-rutin, was absorbed as glycosides into the portal blood. A part of αG-rutin was hydrolyzed to rutin, but not to aglycone, through the intestine. |
| Description URI: | http://www.taylorandfrancisgroup.com/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/15870 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 原 博
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