|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
L-homoarginine suppresses exocrine pancreas in rats.
| Title: | L-homoarginine suppresses exocrine pancreas in rats. |
| Authors: | Hira, Tohru Browse this author | | Ohyama, Sumika Browse this author | | Hara, Hiroshi Browse this author →KAKEN DB |
| Keywords: | L-Homoarginine | | Pancreatic secretion | | Pancreatic hypertrophy | | Bile-pancreatic juice diversion | | Hypercholecystokinemia | | Rat |
| Issue Date: | Jun-2003 |
| Publisher: | Springer |
| Journal Title: | Amino Acids |
| Volume: | 24 |
| Issue: | 4 |
| Start Page: | 389 |
| End Page: | 396 |
| Publisher DOI: | 10.1007/s00726-002-0344-2 |
| PMID: | 12768501 |
| Abstract: | Previously, we found that guanidinated casein, a l-homoarginine-containing protein, was a more potent stimulator of pancreatic enzyme secretion than intact casein in rats. In this study, we examined secretory response and adaptation of the exocrine pancreas to the administration of free l-homoarginine in normal and bile-pancreatic juice (BPJ)-diverted rats. An intraperitoneal injection of l-homoarginine (10mg/rats) produced immediate and transient reduction in pancreatic secretion in BPJ-diverted rats, but not in normal rats. The BPJ-diverted rats were fed with either a 25% casein, 45% casein, or 45% casein diet supplemented with l-homoarginine (19g/kg diet) for 4 days. Feeding of a diet containing l-homoarginine inhibited the pancreatic adaptation induced by the high-protein diet. These results indicate that l-homoarginine has an inhibitory effect on the secretion and production of exocrine pancreatic enzyme in BPJ-diverted rats, and l-homoarginine may have an antagonistic effect on CCK receptors. |
| Rights: | The original publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/15871 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 原 博
|
