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L-homoarginine suppresses exocrine pancreas in rats.

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Title: L-homoarginine suppresses exocrine pancreas in rats.
Authors: Hira, Tohru Browse this author
Ohyama, Sumika Browse this author
Hara, Hiroshi Browse this author →KAKEN DB
Keywords: L-Homoarginine
Pancreatic secretion
Pancreatic hypertrophy
Bile-pancreatic juice diversion
Issue Date: Jun-2003
Publisher: Springer
Journal Title: Amino Acids
Volume: 24
Issue: 4
Start Page: 389
End Page: 396
Publisher DOI: 10.1007/s00726-002-0344-2
PMID: 12768501
Abstract: Previously, we found that guanidinated casein, a l-homoarginine-containing protein, was a more potent stimulator of pancreatic enzyme secretion than intact casein in rats. In this study, we examined secretory response and adaptation of the exocrine pancreas to the administration of free l-homoarginine in normal and bile-pancreatic juice (BPJ)-diverted rats. An intraperitoneal injection of l-homoarginine (10mg/rats) produced immediate and transient reduction in pancreatic secretion in BPJ-diverted rats, but not in normal rats. The BPJ-diverted rats were fed with either a 25% casein, 45% casein, or 45% casein diet supplemented with l-homoarginine (19g/kg diet) for 4 days. Feeding of a diet containing l-homoarginine inhibited the pancreatic adaptation induced by the high-protein diet. These results indicate that l-homoarginine has an inhibitory effect on the secretion and production of exocrine pancreatic enzyme in BPJ-diverted rats, and l-homoarginine may have an antagonistic effect on CCK receptors.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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